TRBV7-8: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

Target Name: TRBV7-8

NCBI ID: G28590

TRBV7-8

Other Name(s): TCRBV7S8 | TCRBV6S2A1N1T | TRBV78 | T cell receptor beta variable 7-8

TRBV7-8: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

TRBV7-8 (TcRBV7S8) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to investigate, and its potential as a drug or biomarker has generated a lot of interest in the scientific community.

TRBV7-8 is a part of the TcR family, which is known for its role in regulating gene expression and cell signaling. The TcR family includes four subfamilies, A, B, C, and D, and TRBV7-8 belongs to the D subfamily. This subfamily is characterized by the presence of a specific RNA structure, which is composed of a hairpin loop and a stem-loop. The stem-loop is a looping region that is responsible for the stability of the RNA molecule, while the hairpin loop is a loop that is formed by the joining of two ends of the RNA molecule.

TRBV7-8 is a non-coding RNA molecule that is expressed in various tissues and cells throughout the body. It is primarily located in the cytoplasm of cells and has been shown to be involved in regulating gene expression and cell signaling. Studies have shown that TRBV7-8 is involved in the regulation of cell proliferation, differentiation, and survival.

One of the most promising aspects of TRBV7-8 is its potential as a drug target. The TcR family is known for its role in regulating gene expression and cell signaling, making it an attractive target for drugs that are designed to modulate these processes. TRBV7-8 has been shown to be involved in the regulation of cell signaling pathways, including the T cell signaling pathway. This makes it a potential target for drugs that are designed to modulate T cell signaling, such as those that are used to treat cancer.

In addition to its potential as a drug target, TRBV7-8 has also been identified as a potential biomarker for several diseases. The detection and quantification of TRBV7-8 levels in tissues and fluids can be used as a diagnostic marker for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. This makes TRBV7-8 an attractive target for diagnostic tests that are used to diagnose and monitor these diseases.

TRBV7-8 has also been shown to have a unique expression pattern in various tissues and cells. Studies have shown that TRBV7-8 is mainly expressed in the brain, heart, and pancreas, and is not expressed in other tissues or cells. This makes TRBV7-8 an attractive target for drugs that are designed to target these specific tissues or cells.

In conclusion, TRBV7-8 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for several diseases. Its unique structure and function have made it an attractive target for researchers to investigate, and its potential as a drug or biomarker has generated a lot of interest in the scientific community. Further studies are needed to fully understand the role of TRBV7-8 in the regulation of gene expression and cell signaling, as well as its potential as a diagnostic marker and drug target.

Protein Name: T Cell Receptor Beta Variable 7-8

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBV7-8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBV7-8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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