Exploring the Potential Applications of LOC286297, a NADP+-Dependent Pseudogene as a Drug Target or Biomarker
Exploring the Potential Applications of LOC286297, a NADP+-Dependent Pseudogene as a Drug Target or Biomarker
Introduction
LOC286297 is a gene located on chromosome 16q22.1, which encodes for the enzyme methylenetetrahydrofolate dehydrogenase (NADP+-dependent). This gene has been implicated in the development and progression of various diseases, including neurodegenerative disorders, liver diseases, and cancer. The discovery of this gene has raised the prospect of using it as a drug target or biomarker for a variety of diseases.
Understanding the Function of LOC286297
The methylenetetrahydrofolate dehydrogenase (NADP+-dependent) enzyme is a crucial enzyme in the metabolism of folate, a B vitamin that plays a vital role in the development and maintenance of cellular DNA. NADP+ is a crucial co-factor for this enzyme, and its levels are often reduced in diseases that are characterized by impaired cellular metabolism, such as neurodegenerative disorders, liver diseases, and cancer.
LOC286297 encodes for an NADP+-dependent enzyme that is critical for the metabolism of folate. This enzyme catalyzes the conversion of methylenetetrahydrofolate to dimethylenetetrahydrofolate, which is then converted to the active form of folate, 5-methylolyl-2-phase dehydrogenase (MTHF). MTHF is a crucial co-factor for several enzymes involved in cellular metabolism, including the DNA double-strand break repair system and the synthesis of DNA, RNA, and proteins.
The Importance of LOC286297 in Cellular Metabolism
LOC286297 is involved in the first step of the folate metabolism, which is the conversion of methylenetetrahydrofolate to dimethylenetrahydrofolate. This conversion is critical for the subsequent steps of folate metabolism, including the synthesis of MTHF and the production of nucleotides for DNA and RNA synthesis.
In addition to its role in folate metabolism, LOC286297 is also involved in the regulation of cellular processes that are critical for the survival and growth of cells. For example, LOC286297 has been shown to play a role in the regulation of cell death, as well as the response to environmental stressors, such as UV radiation and temperature.
Potential Applications of LOC286297 as a Drug Target or Biomarker
The discovery of LOC286297 has raised the prospect of using it as a drug target or biomarker for a variety of diseases. One potential target for LOC286297 is the regulation of cellular processes that are characterized by impaired metabolism, such as neurodegenerative disorders, liver diseases, and cancer.
For example, LOC286297 has been shown to play a role in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In these disorders, the levels of LOC286297 are often reduced, and its function is disrupted, leading to the misfolding of proteins and the formation of neurotoxins that cause the symptoms of the disorders. Targeting LOC286297 with drugs that can restore its function could be a potential therapy for these disorders.
LOC286297 has also been shown to be involved in the regulation of cellular processes that are critical for the survival and growth of cells. For example, LOC286297 has been shown to play a role in
Protein Name: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like Pseudogene
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• general information;
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• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
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• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
LOC286359 | LOC286437 | LOC338694 | LOC339059 | LOC339166 | LOC339260 | LOC339352 | LOC339593 | LOC339666 | LOC339685 | LOC339760 | LOC339975 | LOC340090 | LOC340184 | LOC340512 | LOC343052 | LOC344967 | LOC349160 | LOC374443 | LOC375196 | LOC387720 | LOC388242 | LOC388780 | LOC389199 | LOC389473 | LOC389765 | LOC389831 | LOC389834 | LOC389895 | LOC389906 | LOC390282 | LOC390705 | LOC391092 | LOC391343 | LOC391813 | LOC392180 | LOC392196 | LOC392232 | LOC399783 | LOC399900 | LOC400347 | LOC400464 | LOC400499 | LOC400541 | LOC400576 | LOC400622 | LOC400627 | LOC400682 | LOC400692 | LOC400706 | LOC400707 | LOC400768 | LOC400940 | LOC401021 | LOC401052 | LOC401127 | LOC401261 | LOC401312 | LOC401324 | LOC401357 | LOC401410 | LOC401478 | LOC401480 | LOC401557 | LOC401589 | LOC401703 | LOC401913 | LOC402221 | LOC403312 | LOC407835 | LOC414300 | LOC439933 | LOC440157 | LOC440300 | LOC440311 | LOC440313 | LOC440700 | LOC440864 | LOC440895 | LOC440910 | LOC440982 | LOC441052 | LOC441081 | LOC441087 | LOC441179 | LOC441228 | LOC441239 | LOC441455 | LOC441666 | LOC441722 | LOC441956 | LOC442028 | LOC442497 | LOC497256 | LOC541473 | LOC550113 | LOC553139 | LOC554206 | LOC574080 | LOC606724
