LOC387720: A Potential Drug Target and Biomarker for Collagen Alpha-1(X) Chain
LOC387720: A Potential Drug Target and Biomarker for Collagen Alpha-1(X) Chain
Introduction
Collagen alpha-1(X) chain is a protein that plays a crucial role in the structure and function of connective tissue, including bones, cartilages, and blood vessels. It is composed of four polypeptide chains: alpha-1, alpha-2, alpha-3, and alpha-4. The alpha-1 chain is the longest and consists of 111 amino acids. It contains a unique feature, known as a \"secreted\" domain, which is involved in the interactions with extracellular matrix ( ECM) components. This article will discuss the properties of the potential drug target of LOC387720, a novel gene that encodes for this protein.
Location and Homology
LOC387720 is located on chromosome 16 at position 246.2 and encodes a protein with a calculated molecular weight of 11.9 kDa. It is a member of the Collagen family, which is known for producing flexible and strong connective tissue components. The alpha-1(X) chain is a specific subunit of the alpha-1 chain, as its amino acid sequence is distinct from the other chains.
Homology is a mechanism by which proteins interact with one another, and it is a crucial factor in the development and maintenance of tissues. The alpha-1(X) chain contains a unique feature, known as a \"secreted\" domain, which is involved in the interactions with ECM components. This secreted domain is composed of 20 amino acids and is located at the C-terminus of the protein. It is known to interact with several ECM components, including the cytoskeleton, adhesion molecules, and extracellular matrix (ECM) components.
Functions and Interactions
The alpha-1(X) chain is involved in the formation and maintenance of tight junctions, which are specialized junctions that regulate the movement of cells in various tissues. The tight junctions are composed of two types of transmembrane proteins: zonula occludans and adherens. alpha-1(X) chain is involved in the formation of these types of tight junctions by interacting with the cytoskeleton and other ECM components.
The alpha-1(X) chain also plays a role in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. The alpha-1(X) chain is involved in the formation of tight junctions , which are essential for the formation of adherens junctions, which are the most stable type of cell-cell adhesion.
In addition to its role in cell-cell adhesion, the alpha-1(X) chain is also involved in the regulation of cell migration. When Mobile is used, cells have flowing characteristics and play a role in transporting and repairing wounds and injuries in the organism. Organize, phagocytose and eliminate pathogens, endocrine and transport functions. The 伪-1(X) chain interacts with the cytoskeleton, other extracellular matrix (ECM) components, and extracellular signaling molecules (ESM) to exert its cell migration regulatory effect.
What are the consequences of the mutation in LOC387720?
Mutation is the basis of biological evolution. Mutation occurs randomly and is not directional. However, in some cases, mutations may have deleterious effects on an organism, particularly on protein function. LOC387720 is a gene encoding 伪-1(X) chain. What consequences might its mutation lead to?
According to current genetic studies, mutations in LOC387720 may lead to changes in the structure and function of the 伪-1(X) chain, thereby affecting its location, interactions and intracellular processes within the cell. These changes may have varying degrees of impact on the health of organisms, including effects on biological processes such as growth and development, immune response, metabolic regulation, and apoptosis.
LOC387720 is of high value as a target during drug discovery because its mutations may lead to changes in its function, making it a potential drug target. In addition, mutations in LOC387720 may also lead to its accumulation in the body, thereby increasing its detection value and clinical application prospects as a biomarker.
Conclusion
LOC387720 is a gene encoding 伪-1(X) chain, located on chromosome 16
Protein Name: Collagen Alpha-1(X) Chain
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More Common Targets
LOC388242 | LOC388780 | LOC389199 | LOC389473 | LOC389765 | LOC389831 | LOC389834 | LOC389895 | LOC389906 | LOC390282 | LOC390705 | LOC391092 | LOC391343 | LOC391813 | LOC392180 | LOC392196 | LOC392232 | LOC399783 | LOC399900 | LOC400347 | LOC400464 | LOC400499 | LOC400541 | LOC400576 | LOC400622 | LOC400627 | LOC400682 | LOC400692 | LOC400706 | LOC400707 | LOC400768 | LOC400940 | LOC401021 | LOC401052 | LOC401127 | LOC401261 | LOC401312 | LOC401324 | LOC401357 | LOC401410 | LOC401478 | LOC401480 | LOC401557 | LOC401589 | LOC401703 | LOC401913 | LOC402221 | LOC403312 | LOC407835 | LOC414300 | LOC439933 | LOC440157 | LOC440300 | LOC440311 | LOC440313 | LOC440700 | LOC440864 | LOC440895 | LOC440910 | LOC440982 | LOC441052 | LOC441081 | LOC441087 | LOC441179 | LOC441228 | LOC441239 | LOC441455 | LOC441666 | LOC441722 | LOC441956 | LOC442028 | LOC442497 | LOC497256 | LOC541473 | LOC550113 | LOC553139 | LOC554206 | LOC574080 | LOC606724 | LOC613266 | LOC642131 | LOC642361 | LOC642422 | LOC642502 | LOC642590 | LOC642677 | LOC642730 | LOC642846 | LOC642947 | LOC643201 | LOC643339 | LOC643406 | LOC643441 | LOC643454 | LOC643763 | LOC643855 | LOC643923 | LOC644006 | LOC644083 | LOC644086
