IGLV1-44: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Target Name: IGLV1-44

NCBI ID: G28823

IGLV1-44

Other Name(s): IGLV144 | V1-16 | immunoglobulin lambda variable 1-44 | Immunoglobulin lambda variable 1-44

IGLV1-44: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Inflammatory diseases, such as rheumatoid arthritis, Crohn's disease, and inflammatory bowel disease, affect millions of people worldwide and can cause significant morbidity and mortality. Chronic inflammation in these diseases can lead to progressive damage to the immune system, which contributes to their persistent symptoms. Therefore, the development of new treatments for these conditions is of great importance.

IGLV1-44: A Potential Drug Target

IGLV1-44 is a protein that is expressed in various tissues and cell types, including the lungs, heart, kidneys, and intestines. It is a member of the intergenital lymphoid voltage-regulated gene (IGLR) family, which is characterized by the presence of a variable voltage-regulated gene (VLR) domain. The IGLV1-44 protein has been shown to play a role in the regulation of T cell development and function, and has been identified as a potential drug target for the treatment of inflammatory diseases.

The IGLV1-44 protein is known for its ability to interact with the nuclear factor of T cells (NFAT), a transcription factor that plays a critical role in the development and function of T cells. The NFAT transcription factor is known to play a role in the regulation of immune cell development, and is a potential target for the treatment of inflammatory diseases.

IGLV1-44 has been shown to interact with the NFAT transcription factor in various cellular contexts. For example, studies have shown that IGLV1-44 can bind to the NFAT transcription factor and prevent its phosphorylation, which is known to play a critical role in the regulation of NFAT function. This interaction between IGLV1-44 and NFAT suggests that IGLV1-44 may be a potential drug target for the treatment of inflammatory diseases.

In addition to its interaction with NFAT, IGLV1-44 has also been shown to play a role in the regulation of T cell proliferation and differentiation. For example, studies have shown that IGLV1-44 can promote the proliferation of T cells, and can also influence the development and function of these cells. This suggests that IGLV1-44 may be a potential drug target for the treatment of inflammatory diseases, particularly those that are characterized by chronic inflammation.

IGLV1-44 as a Biomarker

In addition to its potential as a drug target, IGLV1-44 has also been shown to be a potential biomarker for the treatment of inflammatory diseases. The IGLV1-44 protein has been shown to be expressed in various tissues and cell types, including the lungs, heart, kidneys, and intestines, and has been identified as a potential biomarker for the diagnosis and monitoring of inflammatory diseases.

For example, studies have shown that IGLV1-44 can be used as a marker for the diagnosis of rheumatoid arthritis (RA), a chronic inflammatory disease that affects the joints. In these studies, IGLV1-44 has been shown to be expressed in the joints and other tissues, and has been used to monitor the effectiveness of various treatments for RA.

IGLV1-44 has also been shown to be a potential biomarker for the diagnosis of inflammatory bowel disease (IBD), another chronic inflammatory disease that affects the digestive tract. In these studies, IGLV1-44 has been shown to be expressed in the gut and has been used to monitor the effectiveness of various treatments for IBD.

Conclusion

IGLV1-44 is a protein that has been shown to play a role in the regulation of T cell development and function, and has potential as a drug target for the treatment of inflammatory diseases. Its interaction with the NFAT transcription factor suggests that IGLV1-44 may be a valuable

Protein Name: Immunoglobulin Lambda Variable 1-44

Functions: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)

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•   general information;
•   protein structure and compound binding;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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