IKBKE: A Potential Drug Target and Biomarker (G9641)

Target Name: IKBKE

NCBI ID: G9641

IKBKE

IKBKE: A Potential Drug Target and Biomarker

The identification of potential drug targets and biomarkers is a crucial step in the development of new pharmaceuticals. One promising area of research is the study of intracellular signaling pathways, particularly those involved in neurodegenerative diseases. The IkBKE gene, located on chromosome 12, has been identified as a potential drug target and biomarker for several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

IKBKE: The IkBKE gene

The IkBKE gene is a non-coding RNA molecule that plays a role in the intracellular signaling pathway known as the insulin/IGF-1 signaling pathway. This pathway is involved in the regulation of various cellular processes, including cell growth, differentiation, and metabolism. The IkBKE gene is a key regulator of this pathway, and its dysfunction has been implicated in the development of neurodegenerative diseases.

Neurodegenerative diseases are a group of disorders that affect the nervous system and can include conditions such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. These conditions are characterized by the progressive loss of brain cells, leading to a range of symptoms and disabilities. While the exact causes of these diseases are not yet fully understood, they are thought to involve the dysfunction of various signaling pathways, including the insulin/IGF-1 signaling pathway.

IKBKE as a drug target

The IkBKE gene has been identified as a potential drug target for the treatment of neurodegenerative diseases due to its involvement in the insulin/IGF-1 signaling pathway. This pathway is involved in the regulation of cellular processes that are crucial for the survival and growth of brain cells, and its dysfunction has been implicated in the development of neurodegenerative diseases.

Preclinical studies have shown that inhibiting the activity of the IkBKE gene can improve the survival and cognitive function of neurons in models of Alzheimer's disease and Parkinson's disease. Additionally, inhibiting the IkBKE gene has been shown to reduce the formation of toxic neurotransmitters, such as beta-amyloid, in neurodegenerate brain tissue. These findings suggest that targeting the IkBKE gene may be a promising strategy for the development of new treatments for neurodegenerative diseases.

IKBKE as a biomarker

In addition to its potential as a drug target, the IkBKE gene has also been identified as a potential biomarker for the diagnosis and monitoring of neurodegenerative diseases. The IkBKE gene is expressed in various tissues of the brain, including neurons, glial cells, and microglia, and its levels have been shown to be affected by a variety of factors, including neurodegenerate diseases.

Studies have shown that the IkBKE gene is downregulated in neurodegenerate brain tissue, and this downregulation is associated with the dysfunction of the insulin/IGF-1 signaling pathway. This suggests that the IkBKE gene may be a useful biomarker for the diagnosis and monitoring of neurodegenerative diseases. Additionally, since the IkBKE gene is involved in the regulation of cellular processes that are crucial for the survival and growth of brain cells, its levels may also be affected by other factors that affect brain health, such as aging or environmental toxins.

Conclusion

In conclusion, the IkBKE gene has been identified as a potential drug target and biomarker for the treatment of neurodegenerative diseases. Its involvement in the insulin/IGF-1 signaling pathway and its potential as a drug target makes it an attractive target for the development of new treatments for these conditions. Additionally, its potential as a biomarker for the diagnosis and monitoring of neurodegenerative diseases makes it an important tool for the study of these conditions. Further research is needed to fully understand the role of the IkBKE gene in the development and treatment of neurodegenerative diseases.

Protein Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon

Functions: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1

The "IKBKE Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IKBKE comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets