Target Name: IKZF3
NCBI ID: G22806
Review Report on IKZF3 Target / Biomarker Content of Review Report on IKZF3 Target / Biomarker
IKZF3
Other Name(s): Zinc finger protein Aiolos (isoform 6) | Ikaros family zinc finger protein 3 | Aiolos | IKZF3 variant 2 | Aio-del2 | IKAROS family zinc finger 3 | AIOLOS | Zinc finger protein, subfamily 1A, 3 (Aiolos) | zinc finger protein, subfamily 1A, 3 (Aiolos) | IKZF3_HUMAN | IMD84 | IKZF3 variant 1 | IKAROS family zinc finger 3 (Aiolos), transcript variant 2 | Aio-1 | Zinc finger protein Aiolos (isoform 2) | zinc finger DNA binding protein Aiolos | IKAROS family zinc finger 3, transcript variant 2 | AIO | ZNFN1A3 | Zinc finger protein Aiolos (isoform 1) | IKAROS family zinc finger 3, transcript variant 1 | Zinc finger protein Aiolos

IKZF3: A Zinc Finger Protein and Potential Drug Target

Introduction

The zinc finger protein Aiolos (ISOFORM 6) is a key regulator of gene expression and has been implicated in various cellular processes. It is a transmembrane protein that contains a nucleotide-binding oligomerization domain (NBD), a conserved protein-coding region, and a C-terminal extension that includes a zinc finger domain. Zinc finger proteins are a family of non-coding RNAs that play a crucial role in post-transcriptional gene regulation by binding to specific cis-elements in the 3'-untranslated regions of target genes.

IKZF3, also known as Aiolos (ISOFORM 6), is a zinc finger protein that is expressed in various tissues and has been implicated in various cellular processes. It is a key regulator of gene expression, cell signaling, and DNA replication. IKZF3 has been shown to play a crucial role in the regulation of cell proliferation, differentiation, and apoptosis.

Potential Drug Targets

The zinc finger domain of IKZF3 is a known drug target. Zinc finger proteins have been shown to be involved in various cellular processes, including cell signaling, DNA replication, and apoptosis. Therefore, targeting IKZF3 may be a promising strategy for the development of new drugs.

IKZF3 has been shown to play a role in cell proliferation and has been linked to the regulation of cell cycle progression. It has been shown that IKZF3 inhibits the G1-S transition, which is a critical step in the cell cycle and is associated with the growth and development of cancer. Therefore, targeting IKZF3 may be a promising strategy for the development of anti-cancer drugs.

IKZF3 has also been shown to play a role in the regulation of cell apoptosis. Apoptosis is a natural mechanism of cell death that is regulated by various factors, including IKZF3. Therefore, targeting IKZF3 may be a promising strategy for the development of anti-apoptotic drugs.

IKZF3 has been shown to play a role in the regulation of DNA replication. DNA replication is a critical process that is essential for the growth and development of all cells. Therefore, targeting IKZF3 may be a promising strategy for the development of drugs that can inhibit DNA replication in cancer cells.

Conclusion

In conclusion, IKZF3 is a zinc finger protein that has been shown to play a crucial role in various cellular processes. It has been implicated in the regulation of cell proliferation, apoptosis, and DNA replication. Therefore, targeting IKZF3 may be a promising strategy for the development of new drugs. Further research is needed to fully understand the role of IKZF3 in cellular processes and to develop effective new treatments.

Protein Name: IKAROS Family Zinc Finger 3

Functions: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner

The "IKZF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IKZF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IKZF4 | IKZF5 | IL-1 Receptor | IL-10 Receptor | IL-11 receptor | IL-12 receptor | IL-13 receptor | IL-15 receptor | IL-17 Receptor | IL-2 receptor | IL-20 receptor | IL-22 Receptor | IL-23 receptor complex | IL-27 receptor | IL-3 receptor | IL-31 Receptor | IL-4 receptor | IL-5 receptor | IL-6 receptor | IL10 | IL10RA | IL10RB | IL10RB-DT | IL11 | IL11RA | IL12A | IL12A-AS1 | IL12B | IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5