MIR4311: A Drug Target / Disease Biomarker (G100422905)

MIR4311: A Drug Target / Disease Biomarker

MIR4311, also known as interleukin-4 receptor 7 (IL-4R7), is a protein that is expressed in various tissues throughout the body, including the immune system, skin, and tissues. It is a member of the interleukin-4 receptor family, which is a group of cytokines and chemokines that play a critical role in the regulation of immune and inflammatory responses.

One of the key functions of IL-4R7 is its role in the regulation of T cell development and function. T cells are a crucial part of the immune system, as they are responsible for cell-mediated immunity against viruses, bacteria, and other pathogens. T cell development and function are closely regulated by the IL-4R7 signaling pathway, which involves the interactions between the IL-4R7 protein and its downstream targets.

IL-4R7 is a potential drug target for several reasons. First, it is highly expressed in various tissues, making it an attractive target for small molecule inhibitors. Second, its function in T cell development and function is well understood, which can help researchers to identify potential drug targets. Third, the IL-4R7 signaling pathway is relatively simple, which can make it easier to design and implement small molecule inhibitors.

Several studies have identified potential small molecule inhibitors of IL-4R7. One of the most promising compounds is a peptide called PF-1062626, which is a potent inhibitor of IL-4R7 signaling. PF-1062626 was shown to block the effects of IL-4R7 in T cells, and to protect against the development of cancer in animal models.

Another potential small molecule inhibitor of IL-4R7 is a compound called GS-461203, which is a inhibitor of the protein kinase A kinase (AKT). AKT is a critical downstream target of IL-4R7, andGS-461203 has been shown to inhibit the effects of IL-4R7 in T cells, as well as in other cell types.

While small molecule inhibitors of IL-4R7 are an promising area of research, there are also concerns about their potential side effects. For example, inhibitors of IL-4R7 have been shown to cause signaling pathway dysregulation in T cells, which could lead to negative effects on immune function. Therefore, it is important to carefully evaluate the potential side effects of small molecule inhibitors of IL-4R7 before they are used in clinical trials.

In conclusion, IL-4R7 is a protein that plays a critical role in the regulation of T cell development and function. It is a potential drug target due to its high expression in various tissues and its role in the IL-4R7 signaling pathway. While small molecule inhibitors of IL-4R7 are an promising area of research, further studies are needed to fully understand their potential benefits and side effects.

Protein Name: MicroRNA 4311

The "MIR4311 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR4311 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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