RANGRF: A Protein of Potential Therapeutic and Biomarker Applications

Target Name: RANGRF

NCBI ID: G29098

RANGRF

RANGRF: A Protein of Potential Therapeutic and Biomarker Applications

RANGRF (Research Affiliate Network Generator) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling.

RANGRF is known for its role in the regulation of pain perception and neuroinflammation. It is also a potent antagonist of the pain-promoting neurotransmitter effect of substance P, and has been shown to protect against neuroinflammation in various experimental models of disease.

In addition to its potential therapeutic applications, RANGRF is also of interest as a drug target. Several studies have identified potential drug-drug interactions with RANGRF, and several compounds have been shown to interact with RANGRF in both in vitro and in vivo settings.

One of the most promising compounds that has been shown to interact with RANGRF is a small molecule called N-acyl-L-tryptophan (NALP), which is an endogenous ligand for RANGRF. NALP has been shown to activate RANGRF and to interact with RANGRF in a similar way to other GPCRs, such as the insulin receptor.

NALP has been shown to have a variety of physiological effects, including modulating pain perception and inflammation. In addition to its potential therapeutic applications, NALP also has the potential to serve as a biomarker for the diagnosis and monitoring of various neurological and psychiatric disorders.

Another promising compound that has been shown to interact with RANGRF is a peptide called P160, which is a highly specific RANGRF antagonist. P160 has been shown to block the effects of NALP and other RANGRF agonists, and to protect against neuroinflammation in various experimental models of disease.

In addition to its potential therapeutic applications, P160 also has the potential to serve as a biomarker for the diagnosis and monitoring of various neurological and psychiatric disorders.

Overall, RANGRF is a protein that is of great interest to researchers as a drug target and as a biomarker for the diagnosis and monitoring of various neurological and psychiatric disorders. Further research is needed to fully understand the role of RANGRF in cellular signaling and to develop effective therapies based on RANGRF.

Protein Name: RAN Guanine Nucleotide Release Factor

Functions: May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375)

The "RANGRF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RANGRF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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