Target Name: RBBP8
NCBI ID: G5932
Review Report on RBBP8 Target / Biomarker Content of Review Report on RBBP8 Target / Biomarker
RBBP8
Other Name(s): sporulation in the absence of SPO11 protein 2 homolog | retinoblastoma binding protein 8 | CTIP | COM1 | CTBP-interacting protein | Retinoblastoma binding protein 8 | DNA endonuclease RBBP8 (isoform a) | CtBP-interacting protein | DNA endonuclease RBBP8 | Retinoblastoma-interacting protein and myosin-like | SAE2 | Retinoblastoma-interacting myosin-like | RB binding protein 8, endonuclease, transcript variant 1 | RIM | CTIP_HUMAN | Sporulation in the absence of SPO11 protein 2 homolog | RBBP-8 | CtIP | JWDS | RBBP8 variant 1 | SCKL2 | Retinoblastoma-binding protein 8 | RB binding protein 8, endonuclease

The Potential Drug Target RBBP8: A Potential Therapeutic Target forSPORulation in the Absence ofSPO11 Protein 2 Homolog

Introduction

SPORulation is a critical process in the cell division of many organisms, including bacteria and archaea. It is a complex process that involves the recruitment of various proteins to the site of DNA replication, followed by the separation of the replicated DNA molecules. The protein SPO11 is a key regulator of the SPORulation process in E. coli. It plays a crucial role in the recruitment of the other SPO proteins and in the regulation of the timing of the process. However, in the absence of SPO11 protein, the SPORulation process can be affected, and this has led to the study of RBBP8, a protein that can substitute for SPO11 in SPORulation.

In this article, we will explore the potential drug target RBBP8 and its implications as a new therapy for SPORulation-related diseases.

The Importance of SPORulation in Cell Division

SPORulation is a complex process that involves the recruitment of various proteins to the site of DNA replication. It is essential for the regulation of DNA replication in eukaryotic cells, as well as the chromosome segregation in eukaryotes. SPORulation allows for the accurate and timely replication of DNA, which is crucial for the maintenance of genetic accuracy and the development of a proper cell division.

SPO11: TheRegulator of SPORulation in E. coli

SPO11 is a key regulator of the SPORulation process in E. coli. It plays a crucial role in the recruitment of other SPO proteins and in the regulation of the timing of the process. It is a 21 kDa protein that contains a N-terminal alpha -helicase domain, a central 尾-sheet, and a C-terminal T-loop.

In the absence of SPO11, the SPORulation process can be affected. This has led to the study of RBBP8, a protein that can substitute for SPO11 in SPORulation.

RBBP8: A Potential Drug Target

RBBP8 is a 21 kDa protein that was identified as a gene regulated by theSPO11 gene. It is a 19% homolog of the SPO11 protein and has been shown to have similar functions in the SPORulation process. RBBP8 is expressed in the cytoplasm and the nucleus of E. coli cells and is involved in the regulation of SPORulation.

The potential drug target RBBP8 is an attractive target for drug development due to its involvement in the regulation of SPORulation. It is a protein that can substitute for SPO11 in SPORulation, and therefore, it may be a useful target for the treatment of SPORulation-related diseases.

Conclusion

SPORulation is a critical process in the cell division of many organisms, including bacteria and archaea. The protein SPO11 is a key regulator of the SPORulation process in E. coli. In the absence of SPO11, the SPORulation process can be affected. The potential drug target RBBP8 is a protein that can substitute for SPO11 in SPORulation. Further research is needed to understand the full role of RBBP8 in the regulation of SPORulation and its potential as a drug target.

Protein Name: RB Binding Protein 8, Endonuclease

Functions: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:26721387). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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RBBP8NL | RBBP9 | RBCK1 | RBFA | RBFOX1 | RBFOX2 | RBFOX3 | RBIS | RBKS | RBL1 | RBL2 | RBM10 | RBM11 | RBM12 | RBM12B | RBM14 | RBM14-RBM4 | RBM15 | RBM15-AS1 | RBM15B | RBM17 | RBM17P1 | RBM18 | RBM19 | RBM20 | RBM22 | RBM22P1 | RBM23 | RBM24 | RBM25 | RBM26 | RBM26-AS1 | RBM27 | RBM28 | RBM3 | RBM33 | RBM34 | RBM38 | RBM39 | RBM4 | RBM41 | RBM42 | RBM43 | RBM43P1 | RBM44 | RBM45 | RBM46 | RBM47 | RBM48 | RBM48P1 | RBM4B | RBM5 | RBM5-AS1 | RBM6 | RBM7 | RBM8A | RBMS1 | RBMS1P1 | RBMS2 | RBMS2P1 | RBMS3 | RBMS3-AS3 | RBMX | RBMX2 | RBMX2P1 | RBMXL1 | RBMXL2 | RBMXL3 | RBMY1A1 | RBMY1B | RBMY1D | RBMY1F | RBMY1J | RBMY2EP | RBMY2FP | RBP1 | RBP2 | RBP3 | RBP4 | RBP5 | RBP7 | RBPJ | RBPJL | RBPJP2 | RBPMS | RBPMS-AS1 | RBPMS2 | RBSN | RBX1 | RC3H1 | RC3H2 | RCAN1 | RCAN2 | RCAN3 | RCAN3AS | RCBTB1 | RCBTB2 | RCC1 | RCC1L | RCC2