RARRES2: A novel Drug Target and Biomarker for Retinoid-Induced Genetic Transformation

Target Name: RARRES2

NCBI ID: G5919

RARRES2

RARRES2: A novel Drug Target and Biomarker for Retinoid-Induced Genetic Transformation

Introduction

R-reflective acid receptor (RARRES2) is a transcription factor that plays an important role in tissues such as retina and skin. Studies have found that RARRES2 plays an important role in a variety of cancers, such as skin cancer, cervical cancer, and lung cancer. In addition, RARRES2 is closely associated with retinal diseases and neurodegenerative diseases. Therefore, RARRES2 has become a research subject that has attracted much attention. This article will introduce the structure, function and potential of RARRES2 as a drug target and biomarker.

Structure and function of RARRES2

RARRES2 is a transcription factor named after a component of the retinal pigment epithelium (RPE) present in the retina. The function of RARRES2 in the retina is mainly reflected in the proliferation and cell differentiation of retinal pigment epithelial cells. During development, RARRES2 plays a critical role in the proliferation and differentiation of retinal pigment epithelial cells. During adulthood, RARRES2 participates in the renewal and repair of retinal pigment epithelial cells to maintain retinal function.

In addition, RARRES2 also plays an important role in tissues such as skin and liver. Research shows that RARRES2 plays an important role in cancers such as skin, cervical and lung cancers. Activation of RARRES2 can lead to changes in the expression of multiple genes, leading to tumorigenesis. Therefore, by inhibiting the activity of RARRES2, the occurrence and development of tumors can be effectively inhibited.

RARRES2 as a drug target

RARRES2 plays an important role in a variety of cancers and therefore has great potential as a drug target. Currently, inhibitor drugs are a popular drug research direction. These drugs treat tumors by binding to RARRES2 and inhibiting its activity.

Because RARRES2 plays an important role in a variety of cancers, it has become a target of great interest. Many research groups are exploring RARRES2 as a drug target

Protein Name: Retinoic Acid Receptor Responder 2

Functions: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 (PubMed:27716822). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin

The "RARRES2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RARRES2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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