TSPAN33: A Potential Drug Target for Neurodegenerative Diseases

Target Name: TSPAN33

NCBI ID: G340348

TSPAN33

TSPAN33: A Potential Drug Target for Neurodegenerative Diseases

TSPAN33 (Transiently Protected against Neurodegenerative Transmission) is a protein that is expressed in the brain and is known to play a role in the development and progression of neurodegenerative diseases. The protein is a negative regulator of the neurotransmitter synaptophysin (SAPS) and is expressed at high levels in the brain.

Research has shown that TSPAN33 is involved in a number of different processes in the brain, including the regulation of synaptic plasticity, the maintenance of the blood-brain barrier, and the regulation of neurotransmitter release. It is also involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Due to its involvement in these processes, TSPAN33 has been identified as a potential drug target. Studies have shown that TSPAN33 can be targeted with small molecules and antibodies, and that modifying its expression levels can have a therapeutic effect on neurodegenerative diseases.

One approach to targeting TSPAN33 is to use small molecules that can inhibit its activity as a negative regulator of SAPS. Studies have shown that inhibitors of the protein can be effective in animal models of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Another approach to targeting TSPAN33 is to use antibodies that recognize and target the protein. Studies have shown that antibodies against TSPAN33 can be effective in animal models of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a drug target, TSPAN33 is also a potential biomarker for neurodegenerative diseases. The protein is expressed at high levels in the brain and can be used as a diagnostic marker for neurodegenerative diseases.

Studies have shown that TSPAN33 levels are decreased in the brains of individuals with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. This suggests that TSPAN33 may be a useful biomarker for these diseases.

Overall, TSPAN33 is a protein that is involved in a number of different processes in the brain and is potential as a drug target or biomarker for neurodegenerative diseases. Further research is needed to fully understand its role and potential as a therapeutic agent.

Protein Name: Tetraspanin 33

Functions: Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011)

The "TSPAN33 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSPAN33 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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