TTLL11: A Potential Drug Target and Biomarker for Alzheimer's disease

Target Name: TTLL11

NCBI ID: G158135

TTLL11

TTLL11: A Potential Drug Target and Biomarker for Alzheimer's disease

Abstract:

Alzheimer's disease is a debilitating and fatal neurological disorder that affects millions of people worldwide. The underlying cause of this disease is the accumulation of neurofibrillary tangles and senile plaques in the brain, which lead to the progressive loss of brain cells and cognitive decline. There is currently no cure for Alzheimer's disease, and drug development is limited to supportive care and management of symptoms. Therefore, identifying potential drug targets and biomarkers for this disease remains a major focus of research. In this article, we discuss the potential drug target and biomarker for Alzheimer's disease, TTLL11.

Introduction:

Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and senile plaques in the brain. These tangles and plaques are composed of abnormal aggregates of the protein tau and beta-amyloid, respectively, which are thought to contribute to the neurotoxicity and damage caused by these diseases. The accumulation of these tangles and plaques is linked to the progressive loss of brain cells, which results in cognitive decline and the development of Alzheimer's disease.

TTLL11: A Potential Drug Target:

TTLL11 is a protein that is expressed in the brain and is involved in the regulation of the growth and differentiation of neural stem cells. It is a member of the T-ke family, which is known for its role in the development and maintenance of neural stem cells.TTLL11 has been shown to play a role in the regulation of stem cell proliferation and differentiation, and it has been linked to the development of various neurological disorders, including Alzheimer's disease.

Studies have shown that TTLL11 is involved in the regulation of the production of beta-amyloid, which is a hallmark protein of Alzheimer's disease. Beta-amyloid is thought to contribute to the neurotoxicity and damage caused by Alzheimer's disease, as it is involved in the formation of senile plaques, which are thought to contribute to the progressive loss of brain cells in this disease.

In addition, TTLL11 has been shown to play a role in the regulation of the production of neurofibrillary tangles, which are also thought to contribute to the progressive loss of brain cells in Alzheimer's disease. Neurofibrillary tangles are composed of abnormal aggregates of the protein tau, which is thought to contribute to the neurotoxicity and damage caused by Alzheimer's disease.

TTLL11 as a Biomarker:

TTLL11 has also been shown to be involved in the regulation of various cellular processes that are important for the development and maintenance of neural stem cells. This includes the regulation of cell division, the production of proteins involved in cell signaling, and the regulation of the transport of nutrients and waste products into and out of cells.

TTLL11 has also been shown to play a role in the regulation of the production of other proteins that are involved in the development and maintenance of neural stem cells. These include the proteins PDXL1 and PDXL3, which are known to play a role in the regulation of stem cell proliferation and differentiation.

Conclusion:

In conclusion, TTLL11 is a protein that is involved in the regulation of various cellular processes that are important for the development and maintenance of neural stem cells. Its role in the regulation of beta-amyloid, neurofibrillary tangles, and the production of other proteins involved in neural stem cell maintenance makes it a potential drug target for Alzheimer's disease. Further research is needed to determine the exact mechanisms by which TTLL11 contributes to the development and progression of Alzheimer's disease.

Protein Name: Tubulin Tyrosine Ligase Like 11

Functions: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity)

The "TTLL11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TTLL11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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