Target Name: MUC21
NCBI ID: G394263
Review Report on MUC21 Target / Biomarker Content of Review Report on MUC21 Target / Biomarker
MUC21
Other Name(s): MUC-21 | Mucin-21 (isoform 1) | Mucin 21 | Mucin-21 | MGC125609 | MUC21_HUMAN | epiglycanin | C6orf205 | KMQK697 | MUC21 variant 1 | mucin 21, cell surface associated | bCX31G15.2 | Mucin 21, cell surface associated, transcript variant 1 | Epiglycanin

MHC-I Molecules: Unlocking The Power of Antigens

MUC21 is a protein that is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and intestines. It is a member of the major histocompatibility complex (MHC) class I molecules, which are known as major histocompatibility complex class I molecules (MHC-I).

MHC-I molecules are responsible for presenting antigens from the body's environment to T cells, which are the key immune cells that help protect the body against infection and disease. MHC-I molecules are composed of two main regions: the major histocompatibility complex region (MHC-R) and the constant region (C).

The MHC-R region is the region of the MHC-I molecule that contains the antigens that are presented to T cells. This region is made up of three distinct domains: the alpha chain, the beta chain, and the gamma chain. The alpha chain is the longest and is responsible for the antigens that are processed and loaded onto the major histocompatibility complex class I molecule. The beta chain is the second-longest and is responsible for the antigens that are processed and loaded onto the MHC-R. The gamma chain is the shortest and is responsible for the antigens that are processed and loaded onto the MHC-R.

MHC-I molecules are processed by the MHC-R antigen presentation pathway, which is a complex process that involves the interaction between the antigens and the MHC-R molecules. The MHC-R molecules are loaded onto the major histocompatibility complex class I molecule through a process called antigen cross-presentation. This process involves the presentation of the antigens to the major histocompatibility complex class I molecule by various dendritic cells, including dendritic cells that are derived from the skin, hair, and nails, as well as dendritic cells that are derived from the gut.

MHC-I molecules are also involved in the immune response by T cells. T cells are a critical part of the immune system and play a key role in protecting the body against infection and disease. T cells are able to recognize and respond to antigens that are processed and presented by the MHC-R molecules.

One of the things that makes MHC-I molecules so important for the immune response is their ability to present a wide variety of antigens from the body's environment. MHC-R molecules can present antigens from the body's environment, as well as antigens that are derived from foreign sources, such as viruses or bacteria. This allows T cells to be able to recognize and respond to a wide range of potential threats.

In addition to their role in presenting antigens to T cells, MHC-I molecules are also involved in the regulation of the immune response. For example, MHC-I molecules can be used as a drug target to inhibit the activity of antigens that are able to activate T cells and trigger an immune response. This can be useful for treating autoimmune diseases, in which the immune system attacks the body's own tissues.

MHC-I molecules are also involved in the development and maintenance of cancer. For example, MHC-I molecules can be used as a biomarker to predict the prognosis for cancer patients. This is because changes in the expression of MHC-I molecules can occur in cancer cells, and these changes can be used as a indicator of the severity and stage of the disease.

In conclusion, MHC-I molecules are an important part of the immune system and play a critical role in protecting the body against infection and disease. They are also involved in the regulation of the immune response and in the development and maintenance of cancer. As a result, MHC-I molecules make an attractive target for drug development, with potential applications in a wide range of therapeutic areas.

Protein Name: Mucin 21, Cell Surface Associated

The "MUC21 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MUC21 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

MUC22 | MUC3A | MUC3B | MUC4 | MUC5AC | MUC5B | MUC6 | MUC7 | MUC8 | Mucin | MUCL1 | MUCL3 | MUL1 | Multisubunit histone acetyltransferase complex | MUPP | MUS81 | Muscarinic Acetylcholine Receptor (mAChR) | MUSK | MUSTN1 | MUTYH | MVB12A | MVB12B | MVD | MVK | MVP | MX1 | MX2 | MXD1 | MXD3 | MXD4 | MXI1 | MXRA5 | MXRA5Y | MXRA7 | MXRA8 | MYADM | MYADML | MYADML2 | MYB | MYBBP1A | MYBL1 | MYBL2 | MYBPC1 | MYBPC2 | MYBPC3 | MYBPH | MYBPHL | MYC | MYCBP | MYCBP2 | MYCBP2-AS1 | MYCBPAP | MYCL | MYCL-AS1 | MYCLP1 | MYCN | MYCNOS | MYCNUT | MYCT1 | MYD88 | MYDGF | MYEF2 | Myelin Protein | MYEOV | MYF5 | MYF6 | MYG1 | MYH1 | MYH10 | MYH11 | MYH13 | MYH14 | MYH15 | MYH16 | MYH2 | MYH3 | MYH4 | MYH6 | MYH7 | MYH7B | MYH8 | MYH9 | MYHAS | MYL1 | MYL10 | MYL11 | MYL12A | MYL12B | MYL12BP3 | MYL2 | MYL3 | MYL4 | MYL5 | MYL6 | MYL6B | MYL7 | MYL9 | MYLIP | MYLK | MYLK-AS1