MXRA8: A Potential Drug Target and Biomarker (G54587)

Target Name: MXRA8

NCBI ID: G54587

MXRA8

MXRA8: A Potential Drug Target and Biomarker

MXRA8, a gene located on chromosome 6, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique expression patterns and involvement in several well-established cellular pathways make it an attractive target for drug development.

MXRA8 is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes, including cell adhesion, migration, and invasion. It is a key regulator of the TGF-β pathway, which is involved in cell growth, differentiation, and survival. MXRA8 has been shown to regulate the activity of several transcription factors, including TGF-β1, SMAD3, and NF-kappa-B2.

MXRA8 has been associated with several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its expression has been observed in various types of cancer, including breast, ovarian, and colorectal cancer (3,4). Additionally, MXRA8 has been implicated in several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease (5,6).

The TGF-β pathway is a well-established target for drug development in neurodegenerative diseases. MXRA8 has been shown to regulate the activity of TGF-β1, which is a key transcription factor involved in neurodegeneration. MXRA8 has also been shown to play a role in the regulation of intracellular signaling pathways, including the JNK pathway.

In addition to its involvement in the TGF-β pathway, MXRA8 has also been implicated in several other cellular pathways. It has been shown to be involved in the regulation of cell adhesion (9), and it has been implicated in the regulation of cell migration and invasion. MXRA8 has also been shown to play a role in the regulation of gene expression and has been shown to be involved in the regulation of microRNA (miRNA) levels.

MXRA8 has also been shown to be involved in the regulation of cellular signaling pathways that are important for cancer progression. It has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, which is involved in cell survival and proliferation. MXRA8 has also been shown to be involved in the regulation of the NF-kappa-B signaling pathway, which is involved in inflammation and cellular signaling.

In conclusion, MXRA8 is a promising drug target and biomarker for various diseases. Its unique expression patterns and involvement in several well-established cellular pathways make it an attractive target for drug development. Further research is needed to fully understand the role of MXRA8 in disease progression and to develop effective therapies for these diseases.

Protein Name: Matrix Remodeling Associated 8

Functions: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)

The "MXRA8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MXRA8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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