Study: MUS81 Plays A Role in DNA Double-strand Break Repair and Cancer Development
Study: MUS81 Plays A Role in DNA Double-strand Break Repair and Cancer Development
MUS81 (Crossover junction endonuclease MUS81 (isoform 2)) is a protein that is expressed in a variety of cell types, including bacteria, archaea, and eukaryotes. It is a member of the endonuclease family, which includes enzymes that cleave double-stranded DNA.
MUS81 is unique in that it has a specific cleavage mechanism that allows it to cleave DNA specifically at crossover joints. This specificity makes it a potential drug target or biomarker, as drugs that target MUS81 may be able to interfere with its function and have therapeutic effects.
One of the challenges in studying MUS81 is its expression and activity, as it is expressed in a wide range of cell types and can be difficult to purify and detect. However, research into MUS81 has provided some insight into its function and potential as a drug target.
One of the ways that researchers have studied MUS81 is through its knockdown experiments. These experiments have shown that MUS81 is involved in the DNA double-strand break repair process, and that it plays a role in the regulation of DNA replication in eukaryotes.
Additionally, studies have shown that MUS81 is involved in the development of cancer. For example, researchers have found that high levels of MUS81 are associated with the development of breast cancer. This suggests that MUS81 may be a useful biomarker for this disease and may also be a potential drug target.
Another potential mechanism for studying MUS81 is its role in bacterial infections. Many bacteria use endonucleases to manipulate DNA, and MUS81 is one of the endonucleases that they use. This suggests that MUS81 may be involved in the development and spread of many bacterial infections.
Finally, researchers have also studied the potential therapeutic effects of drugs that target MUS81. Many of these drugs are currently in clinical trials for a variety of conditions, including cancer, infection, and inflammation. These drugs work by inhibiting the activity of MUS81, which could potentially interfere with its function and have therapeutic effects.
In conclusion, MUS81 is a protein that is expressed in a variety of cell types and is involved in the DNA double-strand break repair process. Its specific cleavage mechanism and involvement in the regulation of DNA replication, cancer development, and bacterial infections make it a potential drug target or biomarker. Further research is needed to fully understand its function and potential as a therapeutic agent.
Protein Name: MUS81 Structure-specific Endonuclease Subunit
Functions: Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks (PubMed:28575661)
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More Common Targets
Muscarinic Acetylcholine Receptor (mAChR) | MUSK | MUSTN1 | MUTYH | MVB12A | MVB12B | MVD | MVK | MVP | MX1 | MX2 | MXD1 | MXD3 | MXD4 | MXI1 | MXRA5 | MXRA5Y | MXRA7 | MXRA8 | MYADM | MYADML | MYADML2 | MYB | MYBBP1A | MYBL1 | MYBL2 | MYBPC1 | MYBPC2 | MYBPC3 | MYBPH | MYBPHL | MYC | MYCBP | MYCBP2 | MYCBP2-AS1 | MYCBPAP | MYCL | MYCL-AS1 | MYCLP1 | MYCN | MYCNOS | MYCNUT | MYCT1 | MYD88 | MYDGF | MYEF2 | Myelin Protein | MYEOV | MYF5 | MYF6 | MYG1 | MYH1 | MYH10 | MYH11 | MYH13 | MYH14 | MYH15 | MYH16 | MYH2 | MYH3 | MYH4 | MYH6 | MYH7 | MYH7B | MYH8 | MYH9 | MYHAS | MYL1 | MYL10 | MYL11 | MYL12A | MYL12B | MYL12BP3 | MYL2 | MYL3 | MYL4 | MYL5 | MYL6 | MYL6B | MYL7 | MYL9 | MYLIP | MYLK | MYLK-AS1 | MYLK-AS2 | MYLK2 | MYLK3 | MYLK4 | MYLKP1 | MYMK | MYMX | MYNN | MYO10 | MYO15A | MYO15B | MYO16 | MYO16-AS1 | MYO16-AS2 | MYO18A | MYO18B
