Myosin-10: Unlocking Its Potential Drug Targets (G4628)

Target Name: MYH10

NCBI ID: G4628

MYH10

Myosin-10: Unlocking Its Potential Drug Targets

Myosin-10 (MYH10) is a protein that plays a critical role in muscle contraction and relaxation. It is a member of the myosin family, which is known for its role in the mechanical properties of muscles. Despite its importance, MYH10 is not well understood, and there are limited research studies available on its biology and potential drug targets.

The Importance of Myosin-10

Myosin-10 is a key protein that helps regulate muscle contraction and relaxation. It is composed of two subunits, alpha and beta, that are held together by a hydrophobic interaction. This interaction allows the subunits to move along each other and to interact with other proteins that help to regulate myosin-10 function.

One of the key functions of myosin-10 is its role in muscle contraction. When a muscle is stretched, the myosin-10 subunits bind to the myosin ATPase and begin to rotate in the direction of the extension of the muscle. This rotation leads to the formation of a thicker cortical region and a thinner sarcolemma, which allows the muscle to contract. Once the muscle is relaxed, the myosin-10 subunits begin to return to their original positions, allowing the muscle to relax.

Another function of myosin-10 is its role in the regulation of muscle remodeling. After muscle fibers have been stimulated to contract, they begin to shorten and the myosin-10 subunits begin to disassemble. This disassembly leads to the formation of a thicker sarcolemma and the loss of the myosin ATPase, which allows the muscle to relax.

Despite its importance, myosin-10 is not well understood. There are limited research studies available on its biology, and there are no known drug targets that have been identified.

The Potential for Drug Targets

Despite its importance, myosin-10 is an attractive drug target due to its unique biology. One potential reason for this is its role in muscle contraction and relaxation. As a result, drugs that can inhibit myosin-10 function could be useful for treating muscle -related conditions, such as muscle weakness or myopathies.

Another potential reason for targeting myosin-10 is its role in muscle remodeling. Myosin-10 is involved in the regulation of muscle fibers, and drugs that can alter the activity of myosin-10 may be useful for treating muscle-related conditions, such as muscle atrophy or muscle scarring.

Another potential reason for targeting myosin-10 is its role in the regulation of myosin ATPase. Myosin ATPase is a protein that is involved in the regulation of many cellular processes, including muscle contraction and relaxation. Drugs that can alter the activity of myosin ATPase may be useful for treating a variety of conditions that involve muscle contraction and relaxation, such as myopathies and muscle-related pain.

Conclusion

In conclusion, myosin-10 is a protein that plays a critical role in muscle contraction and relaxation. Despite its importance, there are limited research studies available on its biology and potential drug targets. Further research is needed to better understand the role of myosin- 10 in muscle biology and to identify potential drug targets.

Protein Name: Myosin Heavy Chain 10

Functions: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9

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