OR51A2: A Potential Drug Target for Psychiatric Disorders (G401667)
OR51A2: A Potential Drug Target for Psychiatric Disorders
Olfactory receptor family 51 (OR51) is a subfamily of the T cell receptor (TCR) family, which is responsible for mediating the immune response and cell-to-cell communication. OR51 is composed of two genes, OR51A2 and OR51A1, located on chromosome 6p21. OR51A2 is a 194 amino acid protein that is expressed in the central nervous system (CNS), including the brain, spinal cord, and meninges. While OR51A2 is primarily known for its role in modulating pain perception and anxiety, recent studies have suggested that it may also play a significant role in other physiological processes.
The OR51A2 gene is located in the OR51 gene cluster, which is located on the X chromosome. OR51A2 is a single exon gene and has a calculated gene size of 194 amino acids. OR51A2 is expressed in the CNS and is primarily targeted to the dendrites of neurons, where it is involved in the modulation of ion channels and neurotransmitter release.
OR51A2 is a member of the Olfactory receptor family, which is a large superfamily of T cell receptors that play a critical role in mediating sensory experiences, including smell and taste. The Olfactory receptor family consists of over 300 different genes, including OR51A2, which are responsible for the detection and perception of volatile organic compounds (VOCs) in the environment.
The OR51A2 gene is expressed in the CNS and is primarily targeted to the dendrites of neurons. OR51A2 is involved in the modulation of ion channels and neurotransmitter release, which may be important for its role in pain perception and anxiety regulation.
Recent studies have suggested that OR51A2 may be a drug target for several psychiatric and neurological disorders. For example, OR51A2 has been shown to be involved in the modulation of pain perception and anxiety in animal models of depression and anxiety disorders. OR51A2 may also be involved in the regulation of neurotransmitter release, which could be a potential target for disorders such as Parkinson's disease and schizophrenia.
In addition to its potential role in psychiatric and neurological disorders, OR51A2 has also been shown to have potential therapeutic applications in other areas. For example, OR51A2 has been shown to be involved in the regulation of ion channels in the heart, which could make it a potential target for therapies aimed at treating cardiovascular disease. OR51A2 may also be a useful biomarker for tracking the effectiveness of certain treatments in individuals with psychiatric and neurological disorders.
In conclusion, OR51A2 is a protein that is expressed in the CNS and is involved in the modulation of ion channels and neurotransmitter release. While its primary role in modulating pain perception and anxiety is well established, recent studies have suggested that OR51A2 may also play a significant role in other physiological processes. As such, OR51A2 may be a potential drug target or biomarker for a variety of psychiatric and neurological disorders. Further research is needed to fully understand the role of OR51A2 in these processes and to develop effective treatments.
Protein Name: Olfactory Receptor Family 51 Subfamily A Member 2
Functions: Odorant receptor
The "OR51A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR51A2 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1 | OR5D13 | OR5D14 | OR5D16 | OR5D17P | OR5D18 | OR5E1P | OR5F1 | OR5H1 | OR5H14 | OR5H15 | OR5H2 | OR5H4P | OR5H6 | OR5I1 | OR5K1 | OR5K2 | OR5K3 | OR5K4 | OR5L1 | OR5L2 | OR5M1 | OR5M10
