Target Name: OR56A5
NCBI ID: G390084
Review Report on OR56A5 Target / Biomarker Content of Review Report on OR56A5 Target / Biomarker
OR56A5
Other Name(s): olfactory receptor family 56 subfamily A member 5 | Olfactory receptor 56A5 | Olfactory receptor, family 56, subfamily A, member 5 pseudogene | Olfactory receptor family 56 subfamily A member 5 | olfactory receptor, family 56, subfamily A, member 5 pseudogene | O56A5_HUMAN | OR56A5P

OR56A5: A Potential Drug Target and Biomarker

OR56A5, also known as olfactory receptor family 56 subfamily A member 5, is a G protein-coupled receptor (GPCR) that is expressed in the olfactory system of the human nose. OR56A5 is responsible for mediating the sensations of sweet and sour odors. mutations. in the OR56A5 gene have been linked to various disorders, including chronic rhinitis, a common respiratory disease that affects the nasal passages. Therefore, targeting OR56A5 has been identified as a potential drug target for the treatment of respiratory diseases.

OR56A5 Receptor Structure and Function

OR56A5 is a member of the OR56A5 subfamily of GPCRs, which are a family of GPCRs that play a crucial role in mediating sensory sensations. OR56A5 is characterized by a long extracellular domain, a transmembrane region, and an intracellular signaling cascade that involves several kinases and phosphatidylinositol (PI) systems.

The OR56A5 receptor is expressed in the olfactory epithelial cells, which line the nasal passages and are responsible for the sensations of sweet and sour odors. The OR56A5 receptor is activated by low concentrations of agonists, such as mustard oil, and elicits a rapid increase in intracellular Ca2+ levels. This increase in Ca2+ levels triggers the release of various signaling molecules, including neurotransmitters and ion channels, which ultimately results in the perception of the odor.

OR56A5 Mutations and their Implications

Mutations in the OR56A5 gene have been linked to various disorders, including chronic rhinitis, a common respiratory disease that affects the nasal passages. The most common type of mutation is a missense mutation, which results in the substitution of a specific amino acid for a different one. These mutations can alter the structure and function of the OR56A5 receptor, leading to the disruption of its ability to transmit signals.

In addition to missense mutations, OR56A5 can also undergo structural changes due to the presence of post-translational modifications, such as phosphorylation and ubiquitination. These modifications can alter the stability and localization of the OR56A5 receptor, affecting its function.

Targeting OR56A5 as a Drug Target

Targeting OR56A5 as a drug target is an attractive approach for the treatment of respiratory diseases, such as chronic rhinitis. By blocking the activity of OR56A5, drugs can reduce the sensation of odors and alleviate the symptoms of chronic rhinitis.

One of the potential strategies for targeting OR56A5 is the use of small molecules that can inhibit the activity of the OR56A5 receptor. A variety of these molecules have been synthesized and tested as potential drug candidates. One of these molecules is a structurally diverse natural product, called 1-fluorooctyl-4-[3-(4-methoxybenzyl)-7-nitro-2-(2-pyridyl)-1-thiyl]-pyrimidine (FOB), which is a potent inhibitor of OR56A5.

Another potential drug candidate is a small molecule that targets the OR56A5 receptor in a different way, known as an agonist-selective modulator (ASM). This type of modulator can enhance the activity of certain GPCRs while having little or no effect on other GPCRs. One such ASM is a novel compound called N-[4-(4-fluorobutyl)-3-(4

Protein Name: Olfactory Receptor Family 56 Subfamily A Member 5

Functions: Odorant receptor

The "OR56A5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR56A5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1 | OR5D13 | OR5D14 | OR5D16 | OR5D17P | OR5D18 | OR5E1P | OR5F1 | OR5H1 | OR5H14 | OR5H15 | OR5H2 | OR5H4P | OR5H6 | OR5I1 | OR5K1 | OR5K2 | OR5K3 | OR5K4 | OR5L1 | OR5L2 | OR5M1 | OR5M10 | OR5M11 | OR5M3 | OR5M4P | OR5M8 | OR5M9 | OR5P1P | OR5P2 | OR5P3 | OR5T1 | OR5T2 | OR5T3 | OR5V1 | OR5W2 | OR6A2 | OR6B1 | OR6B2 | OR6B3 | OR6C1 | OR6C2 | OR6C3 | OR6C4 | OR6C65 | OR6C70 | OR6C74 | OR6C75 | OR6C76 | OR6F1 | OR6J1 | OR6K2 | OR6K3 | OR6M1 | OR6N1 | OR6N2 | OR6P1 | OR6Q1 | OR6R2P | OR6S1 | OR6T1 | OR6W1P | OR6X1 | OR6Y1 | OR7A10 | OR7A17 | OR7A5 | OR7C1 | OR7C2 | OR7D1P | OR7D2 | OR7D4 | OR7E104P | OR7E109P | OR7E121P | OR7E122P | OR7E125P | OR7E13P | OR7E140P | OR7E14P | OR7E155P