Target Name: OR51E2
NCBI ID: G81285
Review Report on OR51E2 Target / Biomarker Content of Review Report on OR51E2 Target / Biomarker
OR51E2
Other Name(s): OR51E3P | HPRAJ | olfactory receptor family 51 subfamily E member 2 | Prostate specific G-protein coupled receptor | Olfactory receptor family 51 subfamily E member 2 | PSGR | olfactory receptor, family 51, subfamily E, member 3 pseudogene | prostate-specific G-protein coupled receptor | Prostate-specific G-protein coupled receptor | olfactory receptor OR11-16 | Olfactory receptor 51E2 | olfactory receptor, family 52, subfamily A, member 2 | O51E2_HUMAN | Olfactory receptor OR11-16 | Olfactory receptor, family 51, subfamily E, member 3 pseudogene | OTTHUMP00000164514 | %1E2 | Olfactory receptor, family 52, subfamily A, member 2 | OR52A2

OR51E2: A Protein Involved in Neurodegenerative Diseases and Cancer

OR51E2 (OR51E3P) is a protein that is expressed in various tissues of the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the OR family of cytoplasmic proteins, which are involved in various cellular processes, including intracellular signaling, cytoskeletal organization, and stress response. OR51E2 has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a drug target, OR51E2 is being targeted for potential therapeutic intervention.

OR51E2 is a 21-kDa protein that is expressed in the brain, pancreas, and gastrointestinal tract. It is a member of the OR family of cytoplasmic proteins, which are involved in various cellular processes, including intracellular signaling, cytoskeletal organization, and stress response. The OR family of proteins consists of at least 18 different proteins, including OR1, OR2, OR3, OR4, OR5, OR6, OR7, OR8, OR9, OR10, OR11, OR12, OR13, OR14, OR15, OR16, OR17, OR18, and OR19. OR51E2 is a type of OR protein that is expressed in various tissues of the body, including the brain, pancreas, and gastrointestinal tract.

OR51E2 has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, OR51E2 has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. OR51E2 has also been shown to be involved in the development and progression of cancer, including neuroendocrine tumors.

In addition to its role in disease, OR51E2 is also a drug target. Researchers have identified several potential drug targets for OR51E2, including those that are involved in intracellular signaling, cytoskeletal organization, and stress response. These drug targets include the PI3K/AKT signaling pathway, the TOR signaling pathway, and the NLRP1/TOR signaling pathway, among others.

The PI3K/AKT signaling pathway is a well-established drug target that is involved in various cellular processes, including intracellular signaling, angiogenesis, and cell survival. The PI3K/AKT signaling pathway is composed of two main components: the PI3K protein and the AKT protein. The PI3K protein is a large transmembrane protein that is involved in the production of intracellular signaling signals, while the AKT protein is a small protein that is involved in the regulation of cell survival and angiogenesis.

Research has shown that OR51E2 is involved in the PI3K/AKT signaling pathway, and that it plays a role in the regulation of intracellular signaling in various tissues of the body. For example, studies have shown that OR51E2 is involved in the regulation of the AKT/PI3K signaling pathway in cancer cells, and that this involvement may be a potential therapeutic target for cancer treatment.

The TOR signaling pathway is another well-established drug target that is involved in various cellular processes, including intracellular signaling, cell growth, and stress response. The TOR signaling pathway is composed of the TOR protein and the upstream adaptor protein, TOR1. The TOR protein is a large protein that is involved in the regulation of

Protein Name: Olfactory Receptor Family 51 Subfamily E Member 2

Functions: Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity)

The "OR51E2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR51E2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1 | OR5D13 | OR5D14 | OR5D16 | OR5D17P | OR5D18 | OR5E1P | OR5F1 | OR5H1 | OR5H14 | OR5H15 | OR5H2 | OR5H4P | OR5H6 | OR5I1 | OR5K1 | OR5K2 | OR5K3 | OR5K4 | OR5L1 | OR5L2 | OR5M1 | OR5M10 | OR5M11 | OR5M3 | OR5M4P | OR5M8 | OR5M9 | OR5P1P | OR5P2 | OR5P3 | OR5T1 | OR5T2 | OR5T3 | OR5V1