Target Name: MIR18A
NCBI ID: G406953
Review Report on MIR18A Target / Biomarker Content of Review Report on MIR18A Target / Biomarker
MIR18A
Other Name(s): miR-18 | MIRN18 | MIRN18A | hsa-mir-18 | MIRHG1 | mir-18a | miRNA18A | C13orf25 | hsa-mir-18a | MicroRNA 18a | MIR17HG | MIRH1 | hsa-miR-18a-5p | hsa-miR-18a-3p | microRNA 18a | MIR18

Discovering MiR-18a: A Non-Coding RNA Molecule with Potential as A Drug Target

MicroRNA-18a (miR-18a) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to study and develop new treatments.

The discovery of miR-18a

MiR-18a was first identified in the brush border region (intron retention region) of the human genome. The brush border region is a DNA sequence in a gene that does not code for proteins. It plays an important role in the regulation of gene expression. The researchers found that miR-18a is highly conserved in this region and is similar to the high conservation of other known miRNA molecules. This suggests that miR-18a may be a valuable gene and miRNA molecule.

Further studies have shown that miR-18a is expressed in a variety of cancers, including lung cancer, liver cancer, breast cancer, and ovarian cancer. At the same time, the expression level of miR-18a is closely related to the aggressiveness and prognosis of cancer. These findings suggest that miR-18a may be an important drug target or tumor biomarker.

Biological functions of miR-18a

The function of miR-18a in organisms is to control various biological processes by regulating gene expression. By binding to the mRNA of the target gene, miR-18a can regulate the translation, transcription and degradation of the target gene. This regulatory effect usually leads to changes in the expression levels of target genes, thereby affecting biological processes such as cell cycle, proliferation, differentiation, and apoptosis.

The biological significance of miR-18a in tumors

The expression and function of miR-18a in various cancers suggest that it may be a valuable tumor biomarker and drug target. By reducing the expression level of miR-18a, the growth and spread of tumor cells can be inhibited, thereby improving the therapeutic effect.

The therapeutic value of miR-18a

Currently, miR-18a has become a popular drug target, and a variety of studies are ongoing. Among them, the combination treatment of miR-18a and targeted therapeutic drugs has achieved significant results. For example, one study showed that lung cancer patients treated with both miR-18a-targeted therapy and chemotherapy had significantly longer progression-free survival compared with chemotherapy alone.

Biological properties of miR-18a

The biological characteristics of miR-18a include high conservation, wide expression and functional diversity. miR-18a is highly conserved in multiple organisms, suggesting that it may have similar biological functions in different organisms. Meanwhile, miR-18a is expressed in a variety of cancers, suggesting that it may be a valuable tumor biomarker and drug target.

Prospects for drug development of miR-18a

miR-18a is a molecule with broad application prospects. By inhibiting the expression of miR-18a, the growth and spread of tumor cells can be inhibited, thereby improving the therapeutic effect. Currently, miR-18a has become a popular drug target, and a variety of studies are ongoing.

Protein Name: MicroRNA 18a

The "MIR18A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR18A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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