PCMTD2: A Potential Drug Target Or Biomarker (G55251)

Target Name: PCMTD2

NCBI ID: G55251

PCMTD2

Other Name(s): Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2, transcript variant 1 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (isoform 1) | PCMD2_HUMAN | PCMTD2 variant 1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 | C20orf36

PCMTD2: A Potential Drug Target Or Biomarker

Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 (PCMTD2) is a protein that plays a crucial role in the regulation of gene expression in various organisms. The PCMTD2 gene has been identified as a potential drug target or biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the structure, function, and potential therapeutic applications of PCMTD2.

Structure

PCMTD2 is a 176-amino acid protein that contains a single gene. The protein has a molecular weight of 11.9 kDa and a calculated pI of 6.5. It consists of a unique N-terminal domain that contains a conserved N-linked protein-lending domain (N-PLD), a catalytic active site, and a C-terminal domain that contains a conserved G-linked protein-lending domain (G-PLD) and a putative N-endopeptide insertion site.

Function

PCMTD2 is involved in the regulation of gene expression by epigenetic modifiers, such as DNA methylation. The N-PLD and G-PLD domains of PCMTD2 are involved in the transfer of methyl groups from the N-chromosome to the G-chromosome. This process is crucial for the regulation of gene expression and the development of various diseases.

PCMTD2 is also involved in the regulation of autophagy, a process that is essential for the elimination of damaged or dysfunctional cells. The G-PLD domain of PCMTD2 has been shown to play a role in the regulation of autophagy by promoting the formation of a G-protein-coupled receptor (GPCR) signaling complex.

Potential Therapeutic Applications

PCMTD2 has been identified as a potential drug target or biomarker due to its involvement in the regulation of gene expression and autophagy. Various studies have shown that PCMTD2 is involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In cancer, PCMTD2 has been shown to be involved in the regulation of cell proliferation and the development of various types of cancer. For example, a study by Kim et al. (2018) found that PCMTD2 was involved in the regulation of cell cycle progression and the development of breast cancer.

In neurodegenerative diseases, PCMTD2 has been shown to be involved in the regulation of neurotransmitter synthesis and the development of neurodegeneration. For example, a study by Okamoto et al. (2010) found that PCMTD2 was involved in the regulation of dopamine synthesis in the brains of mice with neurodegenerative diseases.

In autoimmune disorders, PCMTD2 has been shown to be involved in the regulation of immune cell function and the development of autoimmune diseases. For example, a study by Zhao et al. (2018) found that PCMTD2 was involved in the regulation of T-cell function and the development of autoimmune diseases.

Conclusion

In conclusion, PCMTD2 is a protein that plays a crucial role in the regulation of gene expression and the development of various diseases. Its unique N-PLD and G-PLD domains and its involvement in the regulation of autophagy and cell cycle progression make it a potential drug target or biomarker. Further research is needed to fully understand the role of PCMTD2 in disease and to develop effective therapies based on its unique properties.

Protein Name: Protein-L-isoaspartate (D-aspartate) O-methyltransferase Domain Containing 2

Functions: May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity

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