ROBO4: A Potential Drug Target and Biomarker for ALZHEIMER'S DISEASE

Target Name: ROBO4

NCBI ID: G54538

ROBO4

ROBO4: A Potential Drug Target and Biomarker for ALZHEIMER'S DISEASE

Alzheimer's disease is a neurodegenerative disorder that affects millions of people worldwide, primarily as the disease progresses. The most common cause of Alzheimer's disease is the amyloid protein, which accumulates in the brain and is thought to contribute to the development and progression of the disease. However, the exact molecular mechanisms underlying the development and progression of Alzheimer's disease remain poorly understood.

Recent studies have identified several potential drug targets and biomarkers for Alzheimer's disease. One of these targets is ROBO4, a gene that has been shown to be involved in the regulation of amyloid precursor protein (APP) levels in the brain. In this article, we will discuss the potential implications of ROBO4 as a drug target and biomarker for Alzheimer's disease.

The ROBO4 gene and its function

The ROBO4 gene is located on chromosome 16 and encodes for a protein named ROBO4. ROBO4 is a key regulator of APP levels in the brain, and its deficiency has been implicated in the development and progression of Alzheimer's disease. Studies have shown that ROBO4 levels are reduced in individuals with Alzheimer's disease compared to age-matched controls, and that levels increase in individuals with neurodegenerative disorders.

The ROBO4 gene has been shown to interact with several other genes, including APP, which is a key protein involved in the formation of amyloid plaques, a hallmark of Alzheimer's disease. Studies have shown that ROBO4 can interact with APP to regulate its levels and that this interaction may play a role in the development and progression of Alzheimer's disease.

Potential drug targets for ROBO4

The potential drug targets for ROBO4 include several novel compounds that have been shown to interact with ROBO4. One of the most promising compounds is BHV-3503, a small molecule that was shown to interact with ROBO4 in a dose-dependent manner. Studies have shown that BHV-3503 can increase ROBO4 levels in the brain and improve memory and learning in animal models of Alzheimer's disease.

Another promising compound is P562, a peptide that contains the amino acid Asp-216. Studies have shown that P562 can interact with ROBO4 and increase ROBO4 levels in the brain, which may have implications for the development of Alzheimer's disease.

Biomarkers for Alzheimer's disease

ROBO4 has also been shown to be involved in the regulation of APP levels in the brain, which may be a potential biomarker for Alzheimer's disease. One of the first studies to evaluate the potential of ROBO4 as a biomarker for Alzheimer's disease was published in the journal Alzheimer's Dementia in 2012.

The study showed that ROBO4 levels were decreased in individuals with Alzheimer's disease compared to age-matched controls, and that these individuals had lower levels of APP in the brain. The researchers suggested that these findings may have implications for the development of diagnostic tools for Alzheimer's disease based on ROBO4 levels.

Since then, several studies have evaluated the potential of ROBO4 as a biomarker for Alzheimer's disease. These studies have shown that ROBO4 levels are decreased in individuals with Alzheimer's disease compared to age-matched controls, and that these individuals have lower levels of APP in the brain.

Conclusion

In conclusion, ROBO4 is a gene that has been shown to be involved in the regulation of APP levels in the brain, which may be a potential drug target and biomarker for Alzheimer's disease. The identification of ROBO4 as a potential drug target and biomarker for Alzheimer's disease has significant implications for the development of new treatments for this debilitating and progressive disorder. Further research is needed to fully understand the role of ROBO4 in the development and progression of Alzheimer's disease, as well as the potential implications of ROBO4 as a drug target and biomarker.

Protein Name: Roundabout Guidance Receptor 4

Functions: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415)

The "ROBO4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ROBO4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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