SPDL1: A Potential Drug Target and Biomarker (G54908)

Target Name: SPDL1

NCBI ID: G54908

SPDL1

SPDL1: A Potential Drug Target and Biomarker

SPDL1 (Spindle apparatus coiled-coil protein 1, transcript variant 5) is a protein that is expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is a key component of the spindle assembly complex, which is a protein complex that plays a critical role in the proper functioning of mitotic spindles.SPDL1 has been shown to be involved in various physiological processes in the body, including cell division, migration, and the regulation of ion channels.

SPDL1 as a Drug Target

SPDL1 has been identified as a potential drug target due to its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In Cancer

SPDL1 has been shown to be involved in the regulation of cell division and has been associated with the development and progression of various types of cancer. For example, studies have shown that high levels of SPDL1 are associated with poor prognosis in patients with pancreatic cancer. Additionally, SPDL1 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. This may contribute to the development of angioresperimentative diseases.

In Neurodegenerative Diseases

SPDL1 has been shown to be involved in the regulation of neuronal function and has been associated with the development of various neurodegenerative diseases. For example, studies have shown that SPDL1 is involved in the regulation of dopamine receptor function and has been associated with the development of Parkinson's disease. Additionally, SPDL1 has been shown to be involved in the regulation of neurotrophic factor (NTF) signaling, which is a critical factor in the support of neuronal survival.

In Autoimmune Disorders

SPDL1 has been shown to be involved in the regulation of immune cell function and has been associated with the development of various autoimmune disorders. For example, studies have shown that SPDL1 is involved in the regulation of T cell function and has been associated with the development of autoimmune disorders such as rheumatoid arthritis.

SPDL1 as a Biomarker

SPDL1 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that SPDL1 levels can be used as a diagnostic marker for pancreatic cancer and as a biomarker for the progression of neurodegenerative diseases. Additionally, SPDL1 has been shown to be involved in the regulation of various signaling pathways and has been potential biomarker for various diseases.

Conclusion

SPDL1 is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further studies are needed to fully understand the role of SPDL1 in these diseases and to develop effective treatments.

Protein Name: Spindle Apparatus Coiled-coil Protein 1

Functions: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100)

The "SPDL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SPDL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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