SPNS2: Potential Drug Target and Biomarker for Alzheimer's (G124976)

Target Name: SPNS2

NCBI ID: G124976

SPNS2

SPNS2: Potential Drug Target and Biomarker for Alzheimer's

SPNS2 (SPN2) is a protein that is expressed in the nervous system and has been shown to play a role in the development and progression of various neurological disorders, including Alzheimer's disease. It is also known as DFNB115, which stands for double-negative beta-115.

SPNS2 is a member of the superfamily of RNA-binding proteins, which includes proteins that regulate gene expression and are involved in a variety of cellular processes. It is found in many different tissues and cells in the body, including the brain.

One of the key functions of SPNS2 is its role in the development and progression of Alzheimer's disease. This is because SPNS2 is involved in the production of a protein called BACE1, which is thought to contribute to the development of neurofibrillary tangles and other hallmarks of Alzheimer's disease.

In addition to its role in the development of Alzheimer's disease, SPNS2 is also involved in the regulation of synaptic plasticity, which is the ability of the nervous system to change and adapt over time. This is important for the formation of new neural connections and the maintenance of existing ones, and is thought to be involved in a variety of neurological disorders, including Alzheimer's disease.

SPNS2 is also involved in the regulation of inflammation, which is a critical part of the immune system's response to harmful substances in the body. This is important for the development and progression of many neurological disorders, including Alzheimer's disease.

Because of its involvement in the development and progression of Alzheimer's disease, SPNS2 is considered a potential drug target. Researchers are currently working to develop drugs that can inhibit the activity of SPNS2 and prevent the formation of BACE1 and other hallmarks of Alzheimer's disease.

In addition to its potential as a drug target, SPNS2 is also a potential biomarker for the diagnosis and progression of Alzheimer's disease. This is because its expression is often reduced in the brains of people with Alzheimer's disease, and may be a useful indicator of the disease's severity and progression.

Overall, SPNS2 is a protein that is involved in many important cellular processes in the nervous system. Its role in the development and progression of Alzheimer's disease makes it a potential drug target, and its potential as a biomarker for the disease makes it an important area of research. Further studies are needed to fully understand the role of SPNS2 in the nervous system and its potential as a drug and biomarker.

Protein Name: SPNS Lysolipid Transporter 2, Sphingosine-1-phosphate

Functions: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:19074308, PubMed:23180825, PubMed:21084291). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:19074308, PubMed:23180825). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function (PubMed:30973865). S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity)

The "SPNS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SPNS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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