A Potential Drug Target or Biomarker: Uncharacterized Protein C11orf84

Target Name: SPINDOC

NCBI ID: G144097

SPINDOC

A Potential Drug Target or Biomarker: Uncharacterized Protein C11orf84

Uncharacterized protein C11orf84 is a protein that has been identified using transcriptomics and other bioinformatics techniques. C11orf84 has been shown to play a crucial role in the regulation of various cellular processes, including cell adhesion, migration, and invasion. Its unique structure and function have led to its potential as a drug target or biomarker. In this article, we will explore the biology of C11orf84, its potential implications as a drug target, and its potential as a biomarker for various diseases.

Structure and Function

C11orf84 is a protein that is expressed in various tissues and cells in the human body. It is a member of the spectinum family, which is characterized by the presence of a spectinum domain in the protein sequence. The spectinum domain is a unique type of protein that is involved in the regulation of actin dynamics and cell signaling.

One of the most significant features of C11orf84 is its unique structure. C11orf84 has a molecular weight of approximately 18 kDa and a calculated pI of 9.6. Its structure is composed of a unique combination of alphahelices and betahelices, which give it a unique flexibility and stability. C11orf84 also has a distinct N-terminus and a C-terminus, which are involved in its interactions with various cellular signaling pathways.

C11orf84 is involved in various cellular processes that are crucial for cell growth, development, and survival. One of the most significant functions of C11orf84 is its role in cell adhesion and migration. C11orf84 has been shown to play a crucial role in the regulation of cell-cell adhesion by interacting with various adhesion molecules, including cadherins and immunoglobulin-like cell adhesion molecules (Ig-CAMs).

In addition to its role in cell adhesion and migration, C11orf84 is also involved in the regulation of cell signaling pathways. It has been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

Potential Drug Target

C11orf84's unique structure and function make it an attractive target for drug development. Several studies have shown that C11orf84 can be targeted by various small molecules, including inhibitors of its activity as a protein kinase. One of the most promising small molecules is a peptide called SPINDOC, which is derived from the N-terminus of C11orf84.

SPINDOC has been shown to interact with C11orf84 and inhibit its activity as a protein kinase. This interaction between SPINDOC and C11orf84 makes it a potential drug target for the treatment of various diseases.

Potential Biomarker

C11orf84 has also been shown to be a potential biomarker for various diseases. Its unique structure and function make it an attractive target for diagnostic studies. Several studies have shown that C11orf84 can be used as a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion

In conclusion, C11orf84 is a protein that has unique structure and function and has the potential to be a drug target or biomarker for various diseases. Its role in the regulation of cell adhesion, migration, and signaling pathways makes it an attractive target for drug development. Its potential as a biomarker for various diseases makes it an attractive target for diagnostic studies. Further research is needed to fully understand the biology of C11orf84 and its potential as a drug

Protein Name: Spindlin Interactor And Repressor Of Chromatin Binding

Functions: Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability (PubMed:29061846). Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271)

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