PRODH: A Protein Involved in Cellular Processes and Disease (G5625)

Target Name: PRODH

NCBI ID: G5625

PRODH

PRODH: A Protein Involved in Cellular Processes and Disease

PRODH (Proline Dehydrogenase (Oxidase) 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It plays a crucial role in the regulation of cell metabolism and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of PRODH is its role in the detoxification of proline, a key structural component of proteins that can be modified to cause disease. Proline is often modified by the addition of Hydroxyl groups, which can give proteins a negative charge and alter their stability and interactions with other molecules. PRODH is involved in the conversion of these modified prolines to their non-modified forms, thereby preventing them from having negative effects on cellular processes.

In addition to its role in protein detoxification, PRODH is also involved in the regulation of cellular signaling pathways. Many proteins that transmit signals in the cell are modified by the addition of Tyrosine, which can interact with a variety of downstream signaling proteins. PRODH is involved in the conversion of these modified proteins to their non-modified forms, thereby enabling them to function properly and maintain proper signaling pathways.

PRODH is also involved in the regulation of inflammation and immune responses. Many diseases, including cancer, are characterized by chronic inflammation and an imbalance in the immune response. PRODH is involved in the detoxification of proline-modified proteins that contribute to inflammation and immune dysregulation. This helps to maintain a healthy immune response and prevent the development of diseases.

PRODH is also a potential drug target in the treatment of various diseases. Its involvement in protein detoxification and regulation of cellular signaling pathways makes it a promising target for the development of new treatments for a variety of conditions. For example, PRODH has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. By targeting PRODH and modifying the proline structure, new treatments for these conditions may be developed.

In addition to its potential as a drug target, PRODH is also a potential biomarker for certain diseases. Its involvement in the regulation of protein detoxification and cellular signaling pathways makes it a useful marker for tracking the progression of certain diseases. For example, PRODH has been shown to be decreased in individuals with certain forms of cancer, which may be a useful biomarker for monitoring the effectiveness of certain treatments.

Overall, PRODH is a protein that plays a crucial role in the regulation of various cellular processes throughout the body. Its involvement in protein detoxification, signaling pathways, and inflammation makes it a potential drug target and biomarker for the treatment of a variety of conditions. Further research is needed to fully understand its functions and potential as a new treatment option.

Protein Name: Proline Dehydrogenase 1

Functions: Converts proline to delta-1-pyrroline-5-carboxylate

The "PRODH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRODH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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