Target Name: RNF20
NCBI ID: G56254
Review Report on RNF20 Target / Biomarker Content of Review Report on RNF20 Target / Biomarker
RNF20
Other Name(s): Ring finger protein 20 | RING-type E3 ubiquitin transferase BRE1A | FLJ11189 | homolog of S. cerevisiae BRE1 | E3 ubiquitin-protein ligase BRE1A | BRE1 E3 ubiquitin ligase homolog | FLJ20382 | KIAA2779 | BRE1-A | Homolog of S. cerevisiae BRE1 | BRE1 | BRE1A | BRE1A_HUMAN | MGC129668 | hBRE1 | ring finger protein 20 | RING finger protein 20 | MGC129667

RNF20: A Potential Drug Target and Biomarker for The RNA-II Pathway

Ring finger protein 20 (RNF20) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key regulator of gene expression in the RNA polymerase II (RNA-II) pathway, which is involved in the production of RNA molecules from DNA templates. RNF20 is a highly conserved protein that is expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract.

The RNA-II pathway is a critical pathway for the production of RNA molecules, which are involved in various cellular processes, including gene regulation, protein synthesis, and immune responses. The RNA-II pathway is composed of several key components, including RNA polymerase II, core RNA-II machinery, and splicing factors. RNA polymerase II is the enzyme that catalyzes the synthesis of RNA from DNA templates, while core RNA-II machinery is responsible for the maintenance of the RNA-II pathway in the cell.

Shutdown of the RNA-II pathway has been associated with various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, identifying potential drug targets and biomarkers for the RNA-II pathway is of great interest.

RNF20 as a drug target

RNF20 has been shown to be involved in various cellular processes, including cell growth, differentiation, and apoptosis. It is a negative regulator of the RNA-II pathway, which means that it promotes the degradation of RNA polymerase II (RNA-II) subunits that are involved in the production of RNA.

RNA-II is a key transcription factor that regulates gene expression in various cellular processes. It is composed of several subunits, including core RNA-II machinery and splicing factors. Core RNA-II machinery is the core component of the RNA-II pathway and is responsible for the synthesis of RNA from DNA templates, while splicing factors are responsible for the post-transcriptional modification of RNA, including splicing and modification.

RNF20 has been shown to interact with several key components of the RNA-II pathway, including RNA-II polymerase II (RNA-II), core RNA-II machinery, and splicing factors. It has been shown that NF20 can inhibit the activity of RNA-II by binding to its active site, which is located on the alpha subunit of RNA-II.

Inhibition of RNA-II by RFN20 has been shown to have various cellular effects, including the inhibition of cell growth, the inhibition of protein synthesis, and the inhibition of apoptosis. Therefore, RFN20 is a potential drug target for the RNA-II pathway.

RNF20 as a biomarker

RNF20 has also been shown to be involved in various cellular processes, including cell growth, apoptosis, and neurodegeneration. Its expression has been observed in various tissues and cells, including the brain, heart, and gastrointestinal tract.

RNF20 has been shown to be involved in the regulation of cellular processes, including cell growth, apoptosis, and neurodegeneration. It has been shown to interact with several key components of the RNA-II pathway, including RNA-II polymerase II (RNA-II ), core RNA-II machinery, and splicing factors. It has been shown that NF20 can inhibit the activity of RNA-II by binding to its active site, which is located on the alpha subunit of RNA-II.

Therefore, NF20 is a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its expression and function may be closely monitored to determine its potential utility as a drug target or biomarker.

Protein Name: Ring Finger Protein 20

Functions: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation

The "RNF20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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