SEMA6A: Role in Cell Adhesion, Migration and Differentiation (G57556)

Target Name: SEMA6A

NCBI ID: G57556

SEMA6A

SEMA6A: Role in Cell Adhesion, Migration and Differentiation

SEMA6A (semaphorin-6A, ISOform 2) is a protein that is expressed in various tissues throughout the body. It is a member of the semaphorin family, which is a diverse superfamily of transmembrane proteins that play a critical role in cell-cell signaling. SEMA6A is one of the most well-studied proteins in the semaphorin family, and it is known for its role in various physiological processes, including cell adhesion, migration, and signaling.

SEMA6A is a 21-kDa protein that is expressed in various tissues, including neural, muscle, and epithelial cells. It is highly homogeneous and has a Mr of 180 kDa. SEMA6A is a transmembrane protein, and it is involved in several different cellular processes, including intercellular signaling, cell migration and cell differentiation.

One of SEMA6A's most well-studied functions is its role in cell adhesion. SEMA6A is known to be involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent the loss of cells. tight junctions are formed by the interaction of the protein transmembrane T-cell adhesion molecule (TCAM), which is a protein that is also known as CD73. SEMA6A plays a key role in the interaction between TCAM and its cytoplasmic tail, allowing TCAM to interact with the cytoplasm and helping to regulate the formation of tight junctions.

Another function of SEMA6A is its role in cell migration. SEMA6A is involved in the regulation of cell migration by several different mechanisms. For example, SEMA6A has been shown to play a role in the regulation of the protrusion of the axon, which is the process by which neurons carry signals from the cell body to the tips of their axons. Additionally, SEMA6A has been shown to be involved in the regulation of the migration of neural stem cells (NSCs) to their final destination in the brain.

SEMA6A is also involved in several signaling pathways. For example, SEMA6A has been shown to play a role in the regulation of the TGF-β pathway, which is a well-studied signaling pathway that is involved in the regulation of cell growth, differentiation, and inflammation. SEMA6A has been shown to interact with the protein Fyn, which is a key regulator of the TGF-β pathway. This interaction between SEMA6A and Fyn allows SEMA6A to regulate the activity of the TGF-β pathway and to influence the behavior of cells.

SEMA6A is also involved in the regulation of cell differentiation. SEMA6A has also been shown to play a role in the regulation of the determination of cell fate, by influencing the activity of the transcription factor, Brn2. the regulation of the expression of genes involved in cell growth and differentiation, such as the genes involved in cell adhesion, migration and in the regulation of the TGF-β pathway.

SEMA6A is also a good candidate as a drug target, due to its various functions and its involvement in several signaling pathways. It is a potential target for small molecule inhibitors, such as those that can modulate the activity of SEMA6A, or those that can modulate the activity of proteins that interact with SEMA6A. Additionally, SEMA6A can be used as a biomarker for certain diseases, such as cancer, due to its involvement in several cellular processes that are affected by these diseases.

In conclusion, SEMA6A is a well-studied protein that is involved in several cellular processes, including

Protein Name: Semaphorin 6A

Functions: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation

The "SEMA6A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SEMA6A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets