Serpina10: A Potential Drug Target and Biomarker for Protease Inhibition

Target Name: SERPINA10

NCBI ID: G51156

SERPINA10

Other Name(s): PZ-dependent protease inhibitor | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Serine (or Cysteine) Proteinase Inhibitor Clade A Member 10 (SERPINA10) | Protein Z-dependent protease inhibitor precursor | Serpin family A member 10, transcript variant 1 | Protein Z-dependent protease inhibitor | Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | PZI | Serpin A10 | ZPI | serpin A10 | Protein-Z dependent proteinase inhibitor | serpin family A member 10 | ZPI_HUMAN | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

Serpina10: A Potential Drug Target and Biomarker for Protease Inhibition

Protease-activated receptor (PARP) is a protein that plays a crucial role in cell signaling and response to various stimuli. PARP is a transmembrane protein that consists of two subunits, p21 and p22, which are involved in the regulation of DNA double-strand break repair. PARP has been implicated in the development and treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Serpina10 (PZ-dependent protease inhibitor) is a protein that has been identified as a potential drug target and biomarker for PARP inhibition. It belongs to the serpine family of proteins, which are known for their role in various cellular processes, including cell signaling, DNA damage repair, and inflammation. In this article, we will discuss the biology of Serpina10, its potential as a drug target, and its potential as a biomarker for PARP inhibition.

Biomarker Potential

Serpina10 has been shown to play a critical role in the regulation of DNA double-strand break repair (DNA repair) and has been implicated in the development of various diseases. One of the most significant findings is that Serpina10 is highly expressed in human tissues, including cancer cells, and that it is involved in the repair of DNA double-strand breaks in these cells.

In addition to its role in DNA repair, Serpina10 has also been shown to play a critical role in cell signaling and cell survival. It has been shown to be involved in the regulation of cell apoptosis, cell cycle progression, and cell migration. These functions are critical for the development and progression of various diseases, including cancer.

Drug Target Potential

Serpina10 has been identified as a potential drug target for PARP inhibition due to its role in DNA repair and its expression in various diseases. Parathyroid hormone (PTH) is a hormone that is involved in the regulation of calcium homeostasis and has been shown to play a critical role in the regulation of DNA repair. PTH has been shown to inhibit the activity of PARP, which is involved in the regulation of DNA double-strand break repair.

Serpina10 has been shown to have a similar structure to PTH and to interact with PARP. Therefore, it is possible that Serpina10 may have similar effects on DNA repair and cell signaling as PTH. This suggests that Serpina10 may be a useful drug target for PARP inhibition.

Conclusion

In conclusion, Serpina10 is a protein that has been identified as a potential drug target and biomarker for PARP inhibition. Its role in DNA repair and its expression in various diseases make it a promising target for drug development. Further research is needed to determine the full potential of Serpina10 as a drug target and biomarker for PARP inhibition.

Protein Name: Serpin Family A Member 10

Functions: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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