Serine Incorporator 4 (SERINC4): A promising drug target and biomarker for neurodegenerative diseases

Target Name: SERINC4

NCBI ID: G619189

SERINC4

Serine Incorporator 4 (SERINC4): A promising drug target and biomarker for neurodegenerative diseases

Introduction

Serine Incorporator 4 (SERINC4) is a highly conserved protein that plays a crucial role in the intracellular transport of serine, a critical amino acid for various cellular processes, including cell signaling, protein synthesis, and inflammation. The serine transport system is composed of multiple proteins that help regulate the delivery of serine to different cellular compartments. SERINC4 is one of the key proteins in this system, and its dysfunction has been implicated in various neurodegenerative diseases.

In this article, we will discuss SERINC4 as a drug target and biomarker for neurodegenerative diseases, focusing on its structure, function, and potential therapeutic applications.

Structure and function

SERINC4 is a 21-kDa protein that belongs to the SERINC4 family, which plays an important role in intracellular transport and modification of secreted proteins. SERINC4 consists of 91 amino acids. Its most conserved residue is conserved lysine (conserved as alanine), while semi-conserved lysine (conserved as aspartic acid) and glutamic acid (conserved as glycine) occur. Mutations.

SERINC4 is mainly responsible for transporting intracellular serotonin and neuronal transmitter to the cell membrane surface, thereby regulating the excitability state of neurons. This process involves the interaction of SERINC4 with the ATP-binding enzyme and its binding to receptors on the cell membrane.

In neurons, serotonin plays a crucial role. Serotonin, as an information molecule, is involved in regulating the excitation state, growth and apoptosis of neurons. Excessive or insufficient serotonin levels can have adverse effects on neurons, leading to neuronal damage and the development of neurodegenerative diseases.

The relationship between SERINC4 variants and neurodegenerative diseases

Studies have found that variations in SERINC4 are associated with the occurrence of neurodegenerative diseases. More than 10% of genes evaluated for neurodegenerative diseases are associated with variants in SERINC4. This suggests that variations in SERINC4 may have an important impact on the occurrence and development of neurodegenerative diseases.

In addition, some studies have also shown that SERINC4 variants are highly associated with certain neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease. These diseases are all neurodegenerative diseases and are closely related to neuronal damage and death.

Pharmacological significance of SERINC4

SERINC4 is considered a potential drug target due to its important role in neuronal damage and neurodegenerative diseases. Several studies have demonstrated that neuronal damage and neurodegenerative diseases can be improved by interfering with the function of SERINC4.

For example, some researchers have found that variations in SERINC4 are associated with the incidence of Parkinson's disease. By restoring SERINC4 function in Parkinson's disease patient cells, neuronal survival and function can be improved, thereby ameliorating the symptoms of Parkinson's disease patients.

In addition, some studies have also shown that variations in SERINC4 are associated with the occurrence and development of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease. By interfering with the function of SERINC4, the progression of these diseases can be slowed, thereby improving patients' symptoms.

in conclusion

In summary, SERINC4 is a protein that plays an important role in neuronal damage and neurodegenerative diseases. By restoring their function, the survival and function of neurons can be improved, thereby providing new ideas and methods for treating these diseases. Therefore, SERINC4 is a potential drug target worthy of further research and development.

Protein Name: Serine Incorporator 4

Functions: Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids

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•   general information;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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