SEPTIN12: A Potential Drug Target and Biomarker for Testicular Tissue Protein Li168

Target Name: SEPTIN12

NCBI ID: G124404

SEPTIN12

SEPTIN12: A Potential Drug Target and Biomarker for Testicular Tissue Protein Li168

Introduction

Testicular tissue protein Li168 is a key regulator of many important biological processes, including germ cell generation and maintenance, spermatogenesis and fertilization, embryonic development and development. SEPTIN12 is a member of the Li168 family protein, which plays an important role in spermatogenesis and fertilization. However, Li168 protein also plays an important role in tumorigenesis. Therefore, SEPTIN12 has become a potential drug target and biomarker.

Mechanism of action of SEPTIN12

SEPTIN12 is a protein belonging to the SEPTIN family, and its encoding gene is SMAD4-like. SEPTIN12 plays an important role in spermatogenesis and fertilization. SEPTIN12 can bind to DNA, thereby inhibiting histone deacetylase (DAC) activity, which is an important DNA damage repair process. This inhibitory effect is reversible and can be observed during mitosis and meiosis.

Oncogenic role of SEPTIN12

SEPTIN12 also plays an important role in multiple tumor types. The expression level of SEPTIN12 is closely related to the prognosis of many tumors, such as prostate cancer, liver cancer, breast cancer, and ovarian cancer. In some tumors, the expression level of SEPTIN12 is related to tumor invasion and metastasis.

Pharmacological significance of SEPTIN12

SEPTIN12 is a potential drug target because it plays an important role in a variety of tumors and is related to tumor invasiveness and metastasis. Inhibition of SEPTIN12 can lead to apoptosis of tumor cells, which has positive significance for tumor treatment. In addition, SEPTIN12 can also be used as a biomarker after tumor treatment to monitor tumor recurrence and metastasis.

Clinical application of SEPTIN12

The application of SEPTIN12 in tumor treatment is also being studied. Some studies have used SEPTIN12 in the treatment of prostate and liver cancer. These studies show that inhibition of SEPTIN12 can lead to apoptosis of tumor cells, thus improving the therapeutic effect.

Biological significance and clinical application of SEPTIN12

SEPTIN12 is a protein that plays an important role in tumorigenesis. Inhibition of SEPTIN12 can lead to apoptosis of tumor cells, which has positive significance for tumor treatment. In addition, SEPTIN12 can also be used as a biomarker after tumor treatment to monitor tumor recurrence and metastasis. Therefore, SEPTIN12 is a potential drug target and biomarker worthy of further study.

Protein Name: Septin 12

Functions: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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