SERPINA12: A Potential Drug Target and Biomarker (G145264)

Target Name: SERPINA12

NCBI ID: G145264

SERPINA12

Other Name(s): serpin family A member 12 | Serpin family A member 12, transcript variant 1 | SPA12_HUMAN | Serpin A12 | Visceral adipose tissue-derived serine protease inhibitor | visceral adipose-specific SERPIN | Vaspin | vaspin | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | visceral adipose tissue-derived serine protease inhibitor | Visceral adipose-specific serpin | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | OL-64 | Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

SERPINA12: A Potential Drug Target and Biomarker

Serpina12 is a member of the serpin family, which is a group of proteins that regulate the entry of various molecular weight of molecules into the endoplasmic reticulum (ER). One of the functions of serpins is to recognize and protect against foreign particles, such as viruses and bacteria, that could pose a threat to the body. In addition to its role in cell signaling, serpins have also been implicated in a number of diseases, including thrombosis, cancer, and neurodegenerative disorders.

The serpin family consists of ten subfamilies, with SERPINA12 being one of the most well-studied. This protein is expressed in a variety of tissues throughout the body, including the liver, spleen, heart, and blood vessels. It is also a potent inhibitor of serine proteases, which are enzymes that break down other proteins. This property makes serpina12 a potential drug target for a number of diseases.

One of the key challenges in studying serpina12 is its complex structure. Serpins are highly conserved, but their variability allows them to interact with a wide range of molecules. As a result, there is still much to be learned about the protein's three-dimensional structure and how it functions. However, research into serpina12 has led to a number of promising leads for new drugs and biomarkers.

One potential drug target for serpina12 is its role in thrombosis. Thrombosis is a serious condition that can lead to blood clots and other complications. Serpins are involved in the regulation of platelet function, which is crucial for the formation of blood clots. In addition, serpins also play a role in the regulation of blood pressure, which is important for maintaining blood flow to the body's tissues. Activating serpins can help to increase platelet function and contribute to thrombosis. Therefore, inhibiting serpina12 activity may be a promising approach to treating thrombosis.

Serpina12 has also been shown to be involved in a number of other processes that are important for human health. For example, it has been shown to play a role in the regulation of inflammation, which is important for maintaining the immune system's response to infection. In addition, serpina12 has also been implicated in the regulation of cell signaling, including the regulation of cell growth and differentiation.

In addition to its potential drug and biomarker applications, serpina12 is also of interest to researchers as a potential therapeutic target for a number of other conditions. For example, it has been shown to be involved in the regulation of the blood-brain barrier, which is responsible for controlling the movement of substances into and out of the brain. This may be of particular interest to researchers studying Alzheimer's disease, which is characterized by the progressive loss of brain cells that are responsible for memory and other cognitive functions.

In conclusion, SERPINA12 is a member of the serpin family that is involved in a number of important processes in the body. Its unique structure and function make it an attractive target for new drugs and biomarkers. Further research is needed to fully understand the protein's role in the regulation of cell signaling and its potential therapeutic applications.

Protein Name: Serpin Family A Member 12

Functions: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues

The "SERPINA12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SERPINA12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets