SENP2: A Potential Drug Target and Biomarker for SUMO1 and Sentrin Inhibition

Target Name: SENP2

NCBI ID: G59343

SENP2

SENP2: A Potential Drug Target and Biomarker for SUMO1 and Sentrin Inhibition

SENP2 (SUMO1/sentrin/SMT3 specific peptidase 2) is a protein that is expressed in various tissues and cells in the human body. It is a key enzyme in the SENP family of proteins, which are involved in the regulation of protein-protein interactions and autophagy process. SENP2 plays an important role in cells, including apoptosis, cell cycle regulation, and cell signaling. In recent years, scientists have discovered that SENP2 is of high value in the field of drug development because it can be studied as a drug target or biomarker. This article will discuss the mechanism of action, drug targets and biomarkers of SENP2.

1. The mechanism of action of SENP2

SENP2 is a hydrolase whose catalytic activity depends on specific substrates. SENP2 can hydrolyze various proteins, including SUMO1, sentrin, and SMT3. These proteins all have important biological functions in cells. For example, SUMO1 plays a role in signaling and cell cycle regulation in cells, sentrin is an important apoptosis regulatory molecule in cells, and SMT3 is involved in apoptosis. By hydrolyzing these proteins, SENP2 can regulate the functions of these proteins and thereby exert their biological effects.

2. Drug targets of SENP2

SENP2 is of high value in the field of drug discovery because it can be studied as a drug target. At present, scientists have discovered many drug targets related to SENP2. Among them, the most important drug target is SENP2 itself. Scientists found that SENP2 is a very conserved protein with a high degree of specificity in its intracellular active site. Therefore, drug intervention targeting SENP2 can effectively inhibit the activity of SENP2, thereby achieving the purpose of treating the disease.

In addition, scientists also discovered a drug target related to SENP2, which is a substrate of SENP2. SENP2 catalyzes the hydrolysis of SUMO1 and sentrin. Therefore, by interfering with the expression of SENP2 substrates, the activity of SENP2 can be effectively inhibited, thereby achieving the purpose of treating diseases.

3. Biomarkers of SENP2

SENP2 is of high value in drug development and disease diagnosis, so scientists have also studied some biomarkers related to SENP2. These biomarkers can reflect the activity status of SENP2, thereby providing important basis for drug development and disease diagnosis.

At present, scientists have discovered many biomarkers related to SENP2. Among them, the most important biomarker is the activity level of SENP2. Scientists have found that the activity level of SENP2 can reflect the level of its substrate, thus providing an important basis for drug development. In addition, scientists also found that the activity level of SENP2 can reflect the binding status of its substrate, thereby providing an important basis for disease diagnosis.

In addition, the scientists also discovered a biomarker related to SENP2, which is the binding state of SENP2 to its substrate. SENP2 can bind to a variety of substrates, including proteins such as SUMO1, sentrin, and SMT3. Therefore, studying the binding state of SENP2 and its substrate can provide important basis for drug development and disease diagnosis.

4. Conclusion

SENP2 is of high value in drug development and disease diagnosis because it can be studied as a drug target or biomarker. At present, scientists have discovered many drug targets related to SENP2, including SENP2 itself and SENP2 substrates. In addition, scientists have also studied a series of biomarkers related to SENP2, which can reflect the activity and binding status of SENP2 and provide important basis for drug development and disease diagnosis. Therefore, future research on SENP2

Protein Name: SUMO Specific Peptidase 2

Functions: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:20194620, PubMed:21965678, PubMed:15296745). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity)

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•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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