IFT80: A Hypervariable Fragment Protein with Potential as A Drug Target Or Biomarker

Target Name: IFT80

NCBI ID: G57560

IFT80

IFT80: A Hypervariable Fragment Protein with Potential as A Drug Target Or Biomarker

IFT80, also known as WD repeat-containing protein 56, is a protein that is expressed in various tissues throughout the body. It is a member of the IFT family, which includes proteins that contain a specific repeat unit. IFT80 is unique because it is the only known protein that contains a repetitive unit composed of a hypervariable fragment (HVF) and a constant region.

The repetitive unit in IFT80 is the polyglutamic acid (PGA) sequence. This sequence is composed of four amino acids, which are repeated in a specific order to form the repeating unit. The PGA sequence is located at the C-terminus of the protein and is responsible for the protein's unique structure and function.

IFT80 is expressed in a variety of tissues, including muscle, heart, brain, and pancreas. It is also expressed in the placenta, which suggests that it may be involved in fetal development and growth.

One of the interesting aspects of IFT80 is its potential as a drug target or biomarker. The PGA sequence makes it a unique target for drug development because it is highly conserved across different species. This means that any drug that is effective against IFT80 should be effective against a wide range of organisms.

In addition, IFT80 is also a good biomarker for certain diseases because it is highly expressed in certain tissues and conditions. For example, IFT80 is highly expressed in the placenta and has been used as a biomarker for pregnancy, fetal growth, and development.

Another potential application of IFT80 is its role in the regulation of cellular processes. IFT80 is involved in a variety of cellular processes, including cell signaling, cell division, and cell adhesion. It is also involved in the regulation of gene expression, which suggests that it may play a role in the development and progression of certain diseases.

IFT80 is also of interest to researchers who are studying the role of repetitive proteins in disease. Repeat proteins are often involved in the development and progression of certain diseases because they can accumulate mutations that contribute to their severity. IFT80 is an example of a repeat protein that has been studied extensively, and its research has implications for our understanding of the role of repetitive proteins in disease.

In conclusion, IFT80 is a unique and fascinating protein that is expressed in various tissues throughout the body. Its unique repetitive unit and its potential as a drug target or biomarker make it an attractive target for research and development. Further studies are needed to fully understand the role of IFT80 in cellular processes and disease.

Protein Name: Intraflagellar Transport 80

Functions: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia

The "IFT80 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IFT80 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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