Target Name: ZNF492
NCBI ID: G57615
Review Report on ZNF492 Target / Biomarker Content of Review Report on ZNF492 Target / Biomarker
ZNF492
Other Name(s): ZN492_HUMAN | Zinc finger protein 115 (Y20) | Zinc finger protein 492 | Zinc finger protein 115 | ZNF115 | zinc finger protein 115 (Y20) | zinc finger protein 492 | KIAA1473

Structure, Function, Drug Targets and Other Aspects of ZNF492: A Review

ZNF492 (ZN492_HUMAN), a protein that belongs to the Zinc Finger Nucleotide (ZFN) family, plays a critical role in cellular signaling. ZNF492 is highly conserved across various species, and its only active center is the nucleotide binding site. ZNF492 plays an important role in various physiological processes, such as cell proliferation, differentiation and tumor formation. At the same time, research also shows that ZNF492 has high value in the field of drug research and development. This article will discuss the structure, function, drug targets and other aspects of ZNF492, aiming to provide certain theoretical support for related research.

1. Structure

ZNF492 consists of 191 amino acids and its molecular weight is 50.0 kDa. ZNF492 has a typical ZFN structure, including an N-terminal zinc finger, a C-terminal zinc finger and an N-terminal non-zinc finger. In addition, ZNF492 also contains an N-terminal helical domain and a C-terminal 伪-helical domain. These domains are highly conserved in function and provide an important structural basis for the stability and biological activity of ZNF492.

2. Function

ZNF492 plays an important role in various physiological processes, such as cell proliferation, differentiation and tumor formation. During the cell proliferation process, ZNF492 participates in the regulation of cell cycle shortening and cell proliferation by regulating the activity of cell cyclins (CDK4 and CDK6). In addition, ZNF492 also plays a key role in cell differentiation. Studies have shown that ZNF492 can regulate multiple signaling pathways in cells, such as Wnt, Notch and Hedgehog, thereby affecting cell differentiation and organogenesis.

In the process of tumor formation, the role of ZNF492 is particularly important. Studies have found that the expression level of ZNF492 is closely related to the prognosis and treatment response of various cancers. For example, the expression level of ZNF492 is negatively correlated with the survival rate, progression-free survival time and overall survival time of breast cancer patients. In addition, the expression level of ZNF492 is also related to the invasion and metastasis capabilities of various cancers. Therefore, studying the tumor inhibitory mechanism of ZNF492 provides new ideas for tumor treatment.

3. Drug Targets

ZNF492 has high value in the field of drug research and development. Since ZNF492 plays an important role in a variety of physiological processes, studying its drug targets is of great significance for drug development. At present, a variety of drug targets have been confirmed to be related to ZNF492, including CDK4, CDK6, Wnt, Notch and Hedgehog. These drug targets not only play important roles in biological processes, but also have extensive pharmacological and clinical application value.

1. CDK4 and CDK6

CDK4 and CDK6 are a pair of CDK (cyclin-dependent kinase) family proteins that play an important role in the cell cycle. Studies have found that ZNF492 can bind to CDK4 and CDK6, thereby regulating their phosphorylation levels. At the same time, ZNF492 can also participate in the regulation of cell cycle shortening and cell proliferation by affecting the phosphorylation activities of CDK4 and CDK6.

2.Wnt

Wnt is a class of conserved proteins that plays an important signal transduction role in a variety of animals. Studies have found that ZNF492 can bind Wnt and thereby participate in processes such as cell proliferation, differentiation, and tumor formation. In addition, ZNF492 can also affect the growth and spread of various cancer cells by regulating the signal transduction activity in the Wnt signaling pathway.

3.Notch

Notch is an important type of transcription factor that plays an important role in a variety of physiological processes. Studies have found that ZNF492 can bind Notch and thereby participate in processes such as cell proliferation, differentiation and tumor formation. In addition, ZNF492 can also affect the growth and spread of various cancer cells by affecting the signal transduction activity in the Notch signaling pathway.

4.Hedgehog

Hedgehog is a conserved transcription factor that plays an important role in a variety of physiological processes. Studies have found that ZNF492 can bind to Hedgehog and thus participate in processes such as cell proliferation, differentiation and tumor formation. In addition, ZNF492 can also affect the signal transduction activity in the Hedgehog signaling pathway.

Protein Name: Zinc Finger Protein 492

Functions: May be involved in transcriptional regulation

The "ZNF492 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF492 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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