RAN: A Protein Involved in Multiple Cellular Processes That Lacks Effective Treatments

Target Name: RAN

NCBI ID: G5901

Content of Review Report on RAN Target / Biomarker

RAN

RAN: A Protein Involved in Multiple Cellular Processes That Lacks Effective Treatments

RAN (OK/SW-cl.81) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and pancreas. It is a member of the TGF-β family of proteins, which are involved in cell growth, differentiation, and survival. RAN is known for its role in the development and maintenance of tissues, as well as its involvement in various signaling pathways.

One of the key functions of RAN is its role in cell signaling. RAN is involved in the formation of the RhoA complex, which is a key component of the cytoskeleton and is involved in the regulation of cell behavior. This complex is composed of the protein RhoA, which is a GTPase that regulates the levels of intracellular GTP, and the protein RhoB, which is a GTPase that regulates the levels of intracellular GTP.

RAN is also involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. RAN plays a key role in the regulation of cell adhesion by controlling the formation of tight junctions, which are specialized structures that mediate the transfer of electrical signals between cells.

In addition to its role in cell signaling and cell adhesion, RAN is also involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. For example, RAN has been shown to play a role in the regulation of neural cell survival and in the development of neurodegenerative diseases.

Despite its involvement in a wide range of cellular processes, RAN is not well understood. There are currently no known drugs that specifically target RAN. This lack of understanding is a major barrier to the development of new treatments for a wide range of diseases.

In conclusion, RAN is a protein that is involved in a wide range of cellular processes, including cell signaling, cell adhesion, and cellular growth and differentiation. Its role in these processes makes it an attractive target for the development of new treatments for a wide range of diseases. Further research is needed to better understand the mechanisms of RAN's role in the development and regulation of tissues, and to identify new treatments for a variety of diseases.

Protein Name: RAN, Member RAS Oncogene Family

Functions: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:17209048, PubMed:26272610, PubMed:27306458). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640)

The "RAN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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