RPUSD4: A Potential Drug Target and Biomarker for Mitochondrial Function

Target Name: RPUSD4

NCBI ID: G84881

RPUSD4

Other Name(s): Mitochondrial RNA pseudouridine synthase RPUSD4 | RNA pseudouridylate synthase domain-containing protein 4 | Pseudouridylate synthase RPUSD4, mitochondrial (isoform a) | RNA pseudouridine synthase D4, transcript variant 2 | RUSD4_HUMAN | RNA pseudouridine synthase D4 | RPUSD4 variant 2 | Pseudouridylate synthase RPUSD4, mitochondrial | RPUSD4 variant 1 | RNA pseudouridylate synthase domain containing 4 | RNA pseudouridine synthase D4, transcript variant 1 | Pseudouridylate synthase RPUSD4, mitochondrial (isoform b)

RPUSD4: A Potential Drug Target and Biomarker for Mitochondrial Function

Mitochondria are essential organelles that play a crucial role in energy metabolism and have been linked to various cellular processes. Mitochondrial dysfunction, characterized by impaired mitochondrial function and dysfunction, has been linked to a wide range of diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. The regulation of mitochondrial function by genes is critical for maintaining cellular homeostasis and has a significant impact on overall cellular health and function.

RPUSD4, or mitochondrial RNA pseudouridine synthase, is a gene that has recently been identified as a potential drug target and biomarker for mitochondrial function. RPUSD4 is a nuclear protein that is primarily localized to the mitochondria and is involved in the synthesis of pseudouridine RNA, a molecule that has been shown to play a role in modulating mitochondrial dynamics and function.

Synonyms: Mitochondrial RNA Pseudouridine Synthase,RPUSD4

Description

RPUSD4 is a protein that is expressed in the mitochondria and is involved in the synthesis of pseudouridine RNA. Pseudouridine RNA is a small RNA molecule that has been shown to play a role in regulating mitochondrial dynamics and function. RPUSD4 has been shown to localize to the mitochondria and to be involved in the synthesis of pseudouridine RNA.

RPUSD4 is a member of the RNA polymerase II (RNA2) family, which is responsible for generating functional RNA molecules in the cytoplasm. RNA2 polymerase is a complex that consists of multiple subunits, including a large subunit (p160) and smaller subunits (p24 and p21), that work together to generate RNA transcripts from DNA templates.

RPUSD4 is localized to the mitochondria and is involved in the synthesis of pseudouridine RNA, which has been shown to play a role in modulating mitochondrial dynamics and function. Pseudouridine RNA has been shown to interact with the protein Drp1, which is involved in the import of foreign particles into the mitochondria.

RPUSD4 has also been shown to be involved in regulating mitochondrial dynamics and function. For example, studies have shown that RPUSD4 is involved in regulating the mitochondrial dynamics of importin 尾, which is a protein that is involved in regulating the import of foreign particles into the mitochondria.

RPUSD4 has also been shown to be involved in the regulation of mitochondrial dynamics and function. For example, studies have shown that RPUSD4 is involved in regulating the mitochondrial dynamics of the protein Drp1, which is involved in the import of foreign particles into the mitochondria.

RPUSD4 has also been shown to play a role in the regulation of cellular processes. For example, studies have shown that RPUSD4 is involved in the regulation of cellular processes such as cell growth, apoptosis, and autophagy.

RPUSD4 is also involved in the regulation of cellular processes. For example, studies have shown that RPUSD4 is involved in the regulation of cellular processes such as cell growth, apoptosis, and autophagy.

RPUSD4 is a potential drug target and biomarker for mitochondrial function because it is involved in the regulation of mitochondrial dynamics and function. Studies have shown that RPUSD4 is involved in the regulation of mitochondrial dynamics and function, which could make it an attractive target for drug development.

Conclusion

RPUSD4 is a gene that is expressed in the mitochondria and is involved in the synthesis of pseudouridine RNA. Pseudouridine RNA is a small RNA molecule that has been shown to play a role in regulating mitochondrial dynamics and function. RPUSD4 has been shown to localize to the mitochondria and to be involved in the synthesis of pseudouridine RNA.

RPUSD4 is a member of the RNA polymerase II (RNA2) family and is involved in the regulation of mitochondrial dynamics and function. Studies have shown that RPUSD4 is involved in the regulation of mitochondrial dynamics and function, which could make it an attractive target for drug development.

RPUSD4 is a potential drug target and biomarker for mitochondrial function because it is involved in the regulation of mitochondrial dynamics and function.

Protein Name: RNA Pseudouridine Synthase D4

Functions: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350)

The "RPUSD4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPUSD4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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