RPS6KA1: Key Regulator of RNA Polymerase II and DNA Replication

Target Name: RPS6KA1

NCBI ID: G6195

RPS6KA1

RPS6KA1: Key Regulator of RNA Polymerase II and DNA Replication

RSK-1 (R PS6KA1) is a protein that is expressed in most tissues of the body and is involved in various cellular processes such as cell signaling, DNA replication, and repair. It is a key regulator of the RNA polymerase II (RPNI) complex, which is responsible for transcription of DNA into RNA. RPNI is a complex that includes several subunits, including RPS6KA1, which is known to play a crucial role in regulating the activity of RPNI.

RPS6KA1 is a key regulator of RPNI activity and is involved in the regulation of gene expression. It functions as a negative regulator of RPNI by binding to its active site and inhibiting its activity. This interaction between RPS6KA1 and RPNI is critical for the regulation of gene expression and is a potential drug target for researchers.

RPS6KA1 is also involved in the regulation of DNA replication and repair. It is a key regulator of the DNA replication machinery and is involved in the regulation of the initiation of DNA replication, elongation, and termination of the replication process. RPS6KA1 is also involved in the regulation of DNA repair, which is critical for the maintenance of genetic integrity in the cell.

In addition to its role in regulating RPNI activity, RPS6KA1 is also involved in the regulation of cellular signaling pathways. It is a key regulator of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular signaling pathways that are important for cellular processes such as cell survival, growth, and angiogenesis. RPS6KA1 is also involved in the regulation of the TOR signaling pathway, which is involved in the regulation of cellular signaling pathways that are important for cell growth, metabolism, and stress resistance.

RPS6KA1 is a protein that is expressed in most tissues of the body and is involved in various cellular processes. It is a key regulator of the RNA polymerase II (RPNI) complex and is involved in the regulation of gene expression, DNA replication, and repair. Its role in these processes makes it a potential drug target for researchers and may have implications for the development of new treatments for various diseases.

Protein Name: Ribosomal Protein S6 Kinase A1

Functions: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404)

The "RPS6KA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPS6KA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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