RPUSD3: A Potential Drug Target and Biomarker for Cancer (G285367)

Target Name: RPUSD3

NCBI ID: G285367

RPUSD3

Other Name(s): RNA pseudouridine synthase D3, transcript variant 1 | Mitochondrial mRNA pseudouridine synthase RPUSD3 | RUSD3_HUMAN | Mitochondrial mRNA pseudouridine synthase RPUSD3 isoform 1 | RPUSD3 variant 1 | RNA pseudouridylate synthase domain-containing protein 3 | RNA pseudouridine synthase D3 | RNA pseudouridylate synthase domain containing 3

RPUSD3: A Potential Drug Target and Biomarker for Cancer

RNA pseudouridine synthase D3 (RPUSD3) is a gene that encodes a protein known for its role in the production of RNA pseudouridine, a derivative of DNA nucleotides that has been shown to play a unique role in various cellular processes. RPUSD3 is a member of the RNA polymerase II (RNA polymerase D) family, which are responsible for producing RNA from DNA templates in the cell.

RPUSD3 is expressed in most tissues and cells of the body, and its function is highly conserved across different species. It is a key enzyme in the production of RNA pseudouridine, which is a modified form of the nucleotide uracil, that has been shown to play a crucial role in various cellular processes, including DNA replication, transcription, and repair.

RPUSD3 is also involved in the regulation of gene expression, and is known to interact with several other proteins that are involved in this process. For example, RPUSD3 has been shown to physically interact with the protein RNA-protein binding factor (RBPF), which is known to play a role in regulating gene expression by binding to specific DNA sequences.

RPUSD3 is a potential drug target, and its role in the production of RNA pseudouridine has led to its investigation as a potential therapeutic agent for a variety of diseases. For example, RPUSD3 has been shown to be involved in the development of cancer, and has been linked to the development of various types of cancer, including breast, ovarian, and prostate cancer.

In addition to its potential as a therapeutic agent, RPUSD3 has also been shown to be a valuable biomarker for the diagnosis and monitoring of various diseases. For example, RPUSD3 has been shown to be elevated in the blood of patients with cancer, and has been used as a biomarker for the diagnosis of cancer in a variety of settings.

RPUSD3 is also a target for researchers who are studying the role of RNA in various cellular processes. Researchers have used RPUSD3 as a tool to study the mechanisms of RNA production and regulation, and have made significant contributions to our understanding of these processes.

In conclusion, RNA pseudouridine synthase D3 (RPUSD3) is a gene that encodes a protein that plays a crucial role in the production of RNA pseudouridine. RPUSD3 is highly conserved across different species and is involved in the regulation of gene expression, as well as the development of cancer. Its potential as a drug target and biomarker make it an attractive target for further research and development.

Protein Name: RNA Pseudouridine Synthase D3

Functions: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664)

The "RPUSD3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPUSD3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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