DUS1L: A Potential Drug Target and Biomarker for tRNA-Dihydrouridine Synthase 1-Like

Target Name: DUS1L

NCBI ID: G64118

DUS1L

DUS1L: A Potential Drug Target and Biomarker for tRNA-Dihydrouridine Synthase 1-Like

Introduction

The tRNA-dihydrouridine synthase 1-like (DUS1L) is a key enzyme in the DNA damage response pathway, which plays a crucial role in the regulation of DNA replication, repair, and quality control. DUS1L is also involved in the repair of DNA double -strand breaks, which are often associated with aging and disease. Given its important role in cellular processes, DUS1L has emerged as a promising drug target and biomarker. In this article, we will discuss the structure and function of DUS1L, its potential as a drug target, and its potential as a biomarker for various diseases.

Structure and Function

DUS1L is a single-chain protein that contains 218 amino acids. It has a molecular weight of 29 kDa and a pre-protein N-terminal peptide of 18 amino acids. DUS1L is localized to the nucleus and is predominantly composed of alpha-helices, beta-helices, and a single alpha-helix. DUS1L has a characteristic Rossmann-fold, which is a structural motif that is commonly found in proteins that play a role in protein-protein interactions.

DUS1L functions as a critical enzyme in the DNA damage response pathway. It is involved in the repair of DNA double-strand breaks, which are often associated with aging and disease. DUS1L has been shown to play a crucial role in the repair of DNA double -strand breaks in both aging cells and cancer cells.

DUS1L is also involved in the regulation of DNA replication, repair, and quality control. It has been shown to be involved in the replication of DNA in the human cell, and it has been shown to play a role in the regulation of DNA replication in various organisms.

Potential as a Drug Target

DUS1L has been shown to be a potential drug target due to its involvement in the DNA damage response pathway. The DNA damage response pathway is a critical pathway that regulates various cellular processes, including DNA replication, repair, and quality control. DUS1L is involved in the regulation of DNA replication, repair, and quality control, making it an attractive target for drugs that aim to modify these processes.

One of the challenges in developing drugs that target DUS1L is its nuclear localization. Unlike other proteins that are primarily cytoplasmic, DUS1L is primarily localized to the nucleus. This is a challenge because drugs that are targeted to the cytoplasm may not be able to reach DUS1L in the nucleus. However, there is ongoing research into new delivery systems that are specifically designed to target the nucleus.

Potential as a Biomarker

DUS1L has also been shown to be a potential biomarker for various diseases. The DNA damage response pathway is involved in the regulation of many cellular processes, including DNA replication, repair, and quality control. , and quality control, making it an attractive target for biomarkers that are used to diagnose and monitor diseases associated with DNA damage.

One of the challenges in developing biomarkers for DUS1L is the difficulty in detecting changes in DUS1L activity in biological samples. Unlike other proteins, DUS1L is primarily localized to the nucleus and is not detectable in cytoplasmic extracts. This is a challenge because many biomarkers are extracted from cytoplasmic extracts and may not be able to detect changes in DUS1L activity in these samples. However, there is ongoing research into new techniques, such as mass spectrometry, that are specifically designed to detect changes in DUS1L activity in biological samples.

Conclusion

In conclusion, DUS1L is a key enzyme that is involved in the regulation of many cellular processes, including DNA replication, repair, and quality control. Its role in

Protein Name: Dihydrouridine Synthase 1 Like

Functions: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs

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