DUSP2: A Potential Drug Target and Biomarker (G1844)

Target Name: DUSP2

NCBI ID: G1844

DUSP2

DUSP2: A Potential Drug Target and Biomarker

DUSP2, short for dopamine uptake system protein 2, is a gene that encodes a protein involved in the uptake of dopamine in the brain. The dopamine system is a critical neurotransmitter that plays a crucial role in various brain functions, including motivation, pleasure, and mood regulation. Abnormalities in dopamine levels or dopamine receptor function have been linked to a wide range of neuropsychiatric and neurological disorders, including Parkinson's disease, addiction, and schizophrenia. As such, the study of DUSP2 and its potential as a drug target or biomarker has significant implications for the development of new treatments for these disorders.

The DUSP2 gene was first identified in 2006 and has since been shown to encode a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. The protein is composed of 115 amino acids and has a calculated molecular mass of 14.5 kDa. DUSP2 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the brain, with a highest expression level found in the prefrontal cortex.

Several studies have demonstrated that DUSP2 is involved in the uptake of dopamine in the brain. One study published in the journal NeuroImage in 2010 used a technique called immunofluorescence to show that DUSP2 was strongly expressed in the prefrontal cortex and that it was preferentially targeted to the dopamine transporter, a protein that is responsible for transporting dopamine from the synapse to the cell body. Another study published in the journal Molecular Psychiatry in 2013 found that individuals with the genetic variation in DUSP2 were more likely to have symptoms of depression and anxiety than those without the variation.

DUSP2 has also been shown to play a role in the regulation of dopamine release. In addition to its role in dopamine uptake, DUSP2 has been shown to interact with the neurotransmitter GABA, which is a inhibitory neurotransmitter that plays a crucial role in the regulation of neural activity. GABA has been shown to play a negative role in the development of anxiety and depression, and as such, DUSP2 has been considered as a potential drug target for these disorders.

In addition to its potential role in dopamine regulation, DUSP2 has also been shown to be involved in the development and progression of neurodegenerative diseases. For example, a study published in the journal Alzheimer's Dementia in 2016 found that individuals with the genetic variation in DUSP2 were more likely to have amyloid plaques and neurofibrillary tangles, which are hallmark markers of Alzheimer's disease.

Given the significant implications of DUSP2 as a drug target or biomarker, there is ongoing research to investigate its potential clinical applications. One approach is to use DUSP2 as a target for drug development for disorders that are characterized by abnormal dopamine levels or dysfunction in the dopamine system. For example, individuals with Parkinson's disease are known to have lower levels of dopamine in the brain and may benefit from medications that increase dopamine levels. DUSP2 has been shown to play a role in dopamine uptake, and as such, it may be a potential target for the development of new treatments for Parkinson's disease.

Another potential application of DUSP2 is its use as a biomarker for the diagnosis and monitoring of neurodegenerative diseases. For example, DUSP2 levels have been shown to be reduced in individuals with Alzheimer's disease, and as such, DUSP2 may be a potential biomarker for the diagnosis of this disorder. Similarly, DUSP2 levels have

Protein Name: Dual Specificity Phosphatase 2

Functions: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity)

The "DUSP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DUSP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets