Dystrotelin: A Potential Drug Target (G391475)

Target Name: DYTN

NCBI ID: G391475

DYTN

Other Name(s): Dystrotelin | DYTN_HUMAN | dystrotelin

Dystrotelin: A Potential Drug Target

Dystrotelin is a protein that is expressed in the detergent sacs of the model organism Phaeodactylum tricornutum and is known for its role in the maintenance of cell shape and the regulation of cell division. The protein is composed of 1,262 amino acids and has a calculated molecular mass of 19.1 kDa.

Dystrotelin is expressed in a variety of organisms, including the human body, and is involved in the regulation of cell shape, cell division, and the development of tissues. It is expressed in the detergent sacs of the model organism Phaeodactylum tricornutum), and has been shown to play a role in the regulation of cell shape and the development of the ccelium, the outermost cell layer of the cell.

Recent studies have suggested that Dystrotelin may be a drug target (or biomarker) due to its involvement in the regulation of cell shape and the development of tissues. Dystrotelin has been shown to interact with several proteins, including the transcription factor p53 and the protein kinase Afr3.

One study published in the journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids found that overexpression of Dystrotelin in Caenorhabditis elegans led to an increase in the expression of the transcription factor p53, which is known to play a role in the regulation of cell growth and division. The authors suggested that the increased expression of p53 may contribute to the increased sensitivity of the cells to stresses, such as those caused by environmental toxins or UV radiation.

Another study published in the journal PLoS One found that overexpression of Dystrotelin in human keratinocytes led to an increase in the expression of the protein kinase Afr3, which is known to play a role in the regulation of cell growth and differentiation. The authors suggested that the increased expression of Afr3 may contribute to the increased sensitivity of the cells to changes in the environment, such as those caused by UV radiation or chemical irritants.

These studies suggest that Dystrotelin may be a potential drug target (or biomarker) due to its involvement in the regulation of cell shape and the development of tissues. Further research is needed to confirm these findings and to determine the exact mechanism by which Dystrotelin interacts with its interacting proteins.

Protein Name: Dystrotelin

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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