E2F2: A Drug Target / Disease Biomarker (G1870)

Target Name: E2F2

NCBI ID: G1870

E2F2

Other Name(s): E2F2_HUMAN | E2F-2 | E2F transcription factor 2 (E2F2) | E2F transcription factor 2 | Transcription factor E2F2

E2F2: A Drug Target / Disease Biomarker

E2F2, also known as SIRT3, is a non-coding RNA molecule that plays a crucial role in cell stress response, DNA damage repair, and cellular senescence. Its function as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for various diseases.

E2F2 is a key regulator of the DNA damage response pathway, which involves the detection and repair of DNA double-strand breaks. During DNA damage, the cell's repair machinery is activated to attempt to repair the damage. However, if the repair process fails, the cell may enter a state of senescence, which is characterized by a series of cellular changes that ultimately lead to the death of the cell.

E2F2 is involved in the regulation of several cellular processes that are critical for maintaining cellular homeostasis. One of its key functions is the regulation of apoptosis, which is the process by which cells undergo programmed cell death. During apoptosis, E2F2 helps to ensure that the cell undergoes proper programmed cell death and that its genetic material is released into the cytoplasm for future reference.

Another function of E2F2 is its role in the regulation of cellular stress response. Stress can cause damage to the cellular infrastructure, leading to dysfunction and the development of various diseases. E2F2 helps to regulate the cellular stress response by ensuring that the cell has the necessary tools to respond to stress, such as the ability to repair damaged DNA.

In addition to its role in the regulation of apoptosis and stress response, E2F2 is also involved in the regulation of cellular senescence. Senescence is a natural process that occurs in all cells, and it is critical for the development and maintenance of multicellular organisms. E2F2 helps to regulate the onset and progression of cellular senescence, ensuring that cells perform their necessary functions until they reach the end of their lifespan.

E2F2 is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and aging. Its involvement in the regulation of apoptosis and stress response makes it an attractive target for therapeutic interventions that can extend lifespan or treat diseases that are characterized by cellular dysfunction.

In conclusion, E2F2 is a non-coding RNA molecule that plays a critical role in cell stress response, DNA damage repair, and cellular senescence. Its function as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for various diseases. Further research is needed to fully understand the role of E2F2 in cellular processes and its potential as a therapeutic intervention.

Protein Name: E2F Transcription Factor 2

Functions: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner

The "E2F2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about E2F2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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