DYRK4: A Potential Drug Target for Cellular Signaling Pathways

Target Name: DYRK4

NCBI ID: G8798

DYRK4

Other Name(s): dual specificity tyrosine phosphorylation regulated kinase 4 | OTTHUMP00000238292 | Dual specificity tyrosine phosphorylation regulated kinase 4, transcript variant 1 | DYRK4 variant 1 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (isoform 1) | dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | OTTHUMP00000238290 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | DYRK4_HUMAN | OTTHUMP00000238291

DYRK4: A Potential Drug Target for Cellular Signaling Pathways

DYRK4 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4) is a protein that plays a crucial role in cellular signaling pathways. It is a member of the tyrosine kinase family and is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. DYRK4 has been identified as a potential drug target and has been the subject of intense research in recent years.

The DYRK4 kinase is composed of 218 amino acid residues and has a molecular weight of 29 kDa. It has a unique structure that consists of a catalytic core and a regulatory module. The catalytic core is composed of a parallel alpha-helices region, a beta -sheet, and a carboxy-region. The regulatory module is composed of a one-dimensional loop and a two-dimensional structure that includes a nucleotide-binding site, a protein-coding region, and a C-terminal hypervariable region (HVR).

DYRK4 is regulated by tyrosine phosphorylation, which is a process that involves the addition of a phosphate group to a specific amino acid residue. Tyrosine phosphorylation is a critical regulatory process that plays a central role in the signaling pathways of many cellular processes. It is involved in the regulation of cell growth, differentiation, angiogenesis, and survival. DYRK4 is a key regulator of tyrosine phosphorylation and its activity is regulated by various factors, including protein kinase (PK), protein tyrosine phosphatases (PTPs), and DNA-binding factors.

DYRK4 has been shown to play a crucial role in the regulation of cellular processes that are important for human health and disease. For example, DYRK4 is involved in the regulation of cell growth and has been shown to play a role in the development of cancer. DYRK4 has also been shown to be involved in the regulation of differentiation and has been shown to play a role in the regulation of neural cell survival.

DYRK4 has also been shown to be a potential drug target. The DYRK4 kinase has been shown to have a high degree of cross-talk with many different drug targets and has been shown to play a role in the regulation of cellular processes that are important for human health and disease. DYRK4 has been shown to be involved in the regulation of cell survival, angiogenesis, and inflammation. It is also thought to play a role in the regulation of immune responses and has been shown to be involved in the regulation of inflammation.

In conclusion, DYRK4 is a protein that plays a crucial role in cellular signaling pathways. It is a member of the tyrosine kinase family and is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. DYRK4 has been identified as a potential drug target and has been the subject of intense research in recent years. Further research is needed to fully understand the role of DYRK4 in cellular signaling pathways and its potential as a drug target.

Protein Name: Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4

Functions: Possible non-essential role in spermiogenesis

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
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