SNAI1: A Potential Drug Target and Biomarker (G6615)

Target Name: SNAI1

NCBI ID: G6615

SNAI1

SNAI1: A Potential Drug Target and Biomarker

SNAI1 (Snail Homolog 1) is a gene that encodes a protein known as snail homolog 1. The protein is expressed in many tissues and has been implicated in various physiological processes in the body. One of the protein's functions is to regulate cell proliferation and has been linked to the development and progression of various diseases. This has led to SNAI1 as a potential drug target and biomarker.

Diseases associated with SNAI1

SNAI1 has been linked to the development and progression of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. One of the most well-known associations is with cancer. Studies have shown that high levels of SNAI1 are associated with poor prognosis in cancer patients. Additionally, SNAI1 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

Potential drug targets

SNAI1 has been identified as a potential drug target due to its involvement in various physiological processes that are associated with the development of diseases. One of the primary targets for SNAI1 is the regulation of cell proliferation. SNAI1 has been shown to play a role in the G1/S checkpoint, a critical regulatory process that regulates cell growth and division.

SNAI1 has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die naturally. This is important for maintaining tissue homeostasis and has been implicated in various diseases, including neurodegenerative diseases.

Another potential target for SNAI1 is its role in cell migration. SNAI1 has been shown to play a role in the regulation of cell migration and has been implicated in the development of various diseases, including cancer.

Biomarkers

SNAI1 has also been identified as a potential biomarker for various diseases. For example, high levels of SNAI1 have been shown to be associated with poor prognosis in cancer patients. Additionally, SNAI1 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. This suggests that SNAI1 may be a useful biomarker for these diseases.

Conclusion

SNAI1 is a gene that encodes a protein that is involved in various physiological processes that are associated with the development of diseases. Its potential as a drug target and biomarker has been identified in the regulation of cell proliferation, apoptosis, and cell migration. Further research is needed to fully understand the role of SNAI1 in diseases and to develop effective treatments.

Protein Name: Snail Family Transcriptional Repressor 1

Functions: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself

The "SNAI1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNAI1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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