AURKA: Potential Drug Target Or Biomarker (G6790)

Target Name: AURKA

NCBI ID: G6790

AURKA

AURKA: Potential Drug Target Or Biomarker

AURKA (AURKA variant 2) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is a key regulator of cell growth and differentiation, and is involved in many important cellular processes.

Recent studies have suggested that AURKA may have potential as a drug target or biomarker. Several studies have shown that inhibiting AURKA can lead to therapeutic effects in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key reasons for the potential of AURKA as a drug target is its involvement in many cellular processes that are important for human health. For example, AURKA is involved in the regulation of cell division, which is critical for the growth and development of tissues. It is also involved in the regulation of cell death, which is important for maintaining tissue homeostasis and preventing disease.

In addition to its role in cell regulation, AURKA has also been shown to play a key role in the development and progression of many diseases. For example, studies have shown that AURKA is often overexpressed in cancer cells, and that inhibiting AURKA can lead to therapeutic effects in these cells. Similarly, AURKA has been shown to be involved in the development of neurodegenerative diseases, and that inhibiting AURKA can lead to therapeutic effects in these conditions.

Another reason for the potential of AURKA as a drug target is its ability to interact with a variety of different signaling pathways. For example, studies have shown that AURKA can interact with the PI3K/Akt signaling pathway, which is involved in many cellular processes that are important for human health. In addition, AURKA can interact with the TGF-β signaling pathway, which is involved in cell regulation and growth.

In conclusion, AURKA is a protein that is expressed in various tissues of the body and is involved in many important cellular processes. Recent studies have suggested that AURKA may have potential as a drug target or biomarker, due to its involvement in cell regulation, its role in the development and progression of many diseases, and its ability to interact with a variety of different signaling pathways. Further research is needed to fully understand the potential of AURKA as a drug target or biomarker.

Protein Name: Aurora Kinase A

Functions: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735)

The "AURKA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AURKA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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