Unlocking The Potential of B3GAT1: A Protein Interacting with NF-Kappa-B

Target Name: B3GAT1

NCBI ID: G27087

B3GAT1

Unlocking The Potential of B3GAT1: A Protein Interacting with NF-Kappa-B

B3GAT1 (NK1) is a protein that is expressed in various tissues throughout the body, including the nervous system, endothelial cells, and epithelial cells. It is a member of the GAT family of proteins, which are known for their ability to interact with DNA and regulate gene expression.

One of the unique features of B3GAT1 is its ability to interact with the transcription factor NF-kappa-B. NF-kappa-B is a protein that plays a role in regulating various cellular processes, including inflammation, cell growth, and differentiation. B3GAT1 has been shown to physically interact with NF-kappa-B and to regulate the expression of genes that are known to be regulated by NF-kappa-B.

This interaction between B3GAT1 and NF-kappa-B has important implications for the function of this protein.NF-kappa-B is known to play a role in the regulation of pain perception, and B3GAT1 has been shown to be involved in the development of pain sensitivity in animal models of pain.

In addition to its interaction with NF-kappa-B, B3GAT1 has also been shown to play a role in the regulation of cellular processes that are important for tissue repair and regeneration. For example, B3GAT1 has been shown to be involved in the regulation of the angiogenic factor, which is responsible for the formation of new blood vessels that contribute to tissue repair after injury or disease.

Despite the many interesting functions that have been attributed to B3GAT1, much more research is needed to fully understand its role in the biology of this protein. One potential avenue for research is to use B3GAT1 as a drug target or biomarker to study the effects of drugs on its function.

For example, researchers could investigate the effects of drugs that interact with B3GAT1 on the activity of NF-kappa-B and on the regulation of pain perception and tissue repair. This could provide valuable insights into the mechanisms of drug action and the potential applications of these drugs in the treatment of various diseases.

Another potential avenue for research is to study the genetic regulation of B3GAT1. Researchers could use techniques such as RNA sequencing to identify the genes that are expressed in B3GAT1 and to determine how these genes are regulated by B3GAT1. This could provide valuable insights into the genetic basis of B3GAT1's function and the potential targets for future research.

Overall, B3GAT1 is a fascinating protein that has the potential to be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role in the biology of this protein and to develop new treatments based on its unique properties.

Protein Name: Beta-1,3-glucuronyltransferase 1

Functions: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group

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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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