Structure and Function of RIPOR1: A Key Regulator of Cell Signaling Pathways

Target Name: RIPOR1

NCBI ID: G79567

RIPOR1

Structure and Function of RIPOR1: A Key Regulator of Cell Signaling Pathways

Rho family-interacting cell polarization regulator 1 (RIPOR1) is a protein that plays a crucial role in cell polarization and cytoskeletal organization. RIPOR1 is a member of the Rho family of GTP-binding proteins, which are known for their ability to regulate cell signaling pathways, including cell division, differentiation, and cytoskeletal organization. RIPOR1 is highly conserved across various species, and its function has been extensively studied in various organisms, including bacteria, yeast, plants, and animals. In this article, we will discuss the structure, function, and potential drug targets of RIPOR1.

Structure

RIPOR1 is a 21-kDa protein that contains 115 amino acid residues. It has a unique structure that consists of a catalytic domain, a transmembrane region, and an intracellular loop. The catalytic domain is the most conserved part of the protein and is involved in the regulation of cell signaling pathways. It contains a catalytic site that is known to have a GTP-binding activity. The transmembrane region is the region that interacts with the cytoskeleton and plays a role in the regulation of cell polarization. The intracellular loop is the region that interacts with various cellular signaling pathways and is involved in the regulation of cell signaling pathways.

Function

RIPOR1 is involved in the regulation of cell signaling pathways, including cell division, differentiation, and cytoskeletal organization. It is a key regulator of the Rho family of GTP-binding proteins, and its function is to regulate the cytoskeleton and the cytoplasm. RIPOR1 plays a role in the regulation of cell division by preventing the movement of the chromosomes to the opposite ends of the cell during the G1 phase of the cell cycle. It also plays a role in the regulation of cell differentiation by promoting the formation of the ploidy stage during the S phase of the cell cycle. RIPOR1 is also involved in the regulation of cytoskeletal organization by interacting with the microtubules of the

Protein Name: RHO Family Interacting Cell Polarization Regulator 1

Functions: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006)

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