EPHX3: Potential Drug Target and Biomarker for Various Diseases

Target Name: EPHX3

NCBI ID: G79852

EPHX3

EPHX3: Potential Drug Target and Biomarker for Various Diseases

EPHX3 (Eph receptor kinase X3) is a protein that is expressed in various tissues and cell types in the human body. It is a member of the Eph receptor tyrosine kinase family, which is a subfamily of the tyrosine kinase family that is involved in cell signaling. EPHX3 is highly expressed in the brain and is involved in the development and maintenance of various tissues, including the nervous system, eye, and cardiovascular system.

One of the key functions of EPHX3 is its role in the development and maintenance of the nervous system. EPHX3 is involved in the regulation of neuronal survival and proliferation, as well as the formation of neural connections. It is also involved in the regulation of pain perception and the regulation of the blood-brain barrier.

In addition to its role in the nervous system, EPHX3 is also involved in the development and maintenance of other tissues. For example, it is highly expressed in the eye, where it is involved in the regulation of retinal cell survival and the formation of neural connections. It is also involved in the regulation of inflammation and immune response.

EPHX3 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. It is also a potential biomarker for these diseases, as its expression levels may be able to provide insight into the severity and progression of these conditions.

One of the key advantages of EPHX3 as a drug target is its expression in various tissues and cell types. This makes it difficult to target the protein directly, but it also means that there is potential for repurposed existing drugs that target other proteins that are expressed at similar levels. For example, EPHX3 is highly expressed in the brain, and drugs that are already approved for use to treat conditions such as Alzheimer's disease and Parkinson's disease may be effective against EPHX3-related diseases.

Another advantage of EPHX3 is its involvement in the regulation of various signaling pathways. It is involved in the regulation of the Wnt signaling pathway, which is involved in the development and maintenance of tissues, including the nervous system. It is also involved in the regulation of theNotch signaling pathway, which is involved in the regulation of cell survival and proliferation.

In addition to its involvement in signaling pathways, EPHX3 is also involved in the regulation of cellular processes that are important for tissue development and maintenance. For example, it is involved in the regulation of cell adhesion, which is important for the formation of tissues and organs. It is also involved in the regulation of cell migration, which is important for the formation of neural connections and the development of tissues.

EPHX3 is also involved in the regulation of pain perception and the regulation of the blood-brain barrier. This suggests that it may be a useful target for pain management and neurodegenerative diseases.

In conclusion, EPHX3 is a protein that is involved in the development and maintenance of various tissues and cells in the human body. It is a member of the Eph receptor tyrosine kinase family and is highly expressed in the brain. As a potential drug target and biomarker, EPHX3 is a promising target for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of EPHX3 in these conditions and to develop effective treatments.

Protein Name: Epoxide Hydrolase 3

Functions: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin

The "EPHX3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EPHX3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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