ERFE: A Protein Interaction Hub for Cell Regulation and Drug Targets

Target Name: ERFE

NCBI ID: G151176

ERFE

ERFE: A Protein Interaction Hub for Cell Regulation and Drug Targets

ERFE (Ezrin-related factor E) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the FAM132B family, which is a group of proteins that are characterized by the presence of a specific domain called the FAM132B signature.

One of the unique features of ERFE is its ability to interact with various proteins, including the cytoskeleton and the endoplasmic reticulum. This interaction between ERFE and these proteins is important for the regulation of various cellular processes, including cell division, migration, and the transport of molecules within the cell.

In addition to its role in cell regulation, ERFE is also a potential drug target. Its interaction with the cytoskeleton and endoplasmic reticulum makes it a promising target for small molecules that can modulate these processes and potentially have therapeutic applications.

ERFE has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of ERFE are associated with poor prognosis in patients with pancreatic cancer, a highly aggressive form of cancer.

In addition to its potential clinical applications, ERFE is also a valuable research tool for scientists who are interested in understanding the underlying mechanisms of its function. The FAM132B signature is a unique and conserved domain that is found in a variety of proteins, including ERFE, and is involved in the regulation of various cellular processes.

Overall, ERFE is a protein that continues to be an important player in the study of protein biology and the regulation of cellular processes. Its interaction with the cytoskeleton and endoplasmic reticulum makes it a promising target for small molecules, and its role in the development and progression of various diseases makes it a valuable tool for researchers. Further research is needed to fully understand the functions of ERFE and its potential as a drug target.

Protein Name: Erythroferrone

Functions: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake

The "ERFE Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ERFE comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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